Παναγιωτης
Μέλος του προσωπικού
Δυναμωστε το Regaine η αποιαδηποτε μινοξιδιλη σας απλα
- Έναρξη μίζας Παναγιωτης
- Ημερομηνία έναρξης
- Κατάσταση
Παρακαλώ συνδεθείτε ή εγγραφείτε για να απενεργοποιήσετε τις διαφημίσεις.
Απ: Δυναμωστε το Regaine η αποιαδηποτε μινοξιδιλη σας απλα
Η ερευνα που διάβασα εγω ειναι η ακολουθη. Αποδεικνυει μαλλιστα πως η tretinoin εχει δραση regrowth οταν εφαρμοζεται μονη της. Ο dr Lee πουλαει διαλυμα minoxidil-tretinoin, αλλα μου φαινεται λιγο ακριβουτσικη. Τελικα ξερει κανεις αν μπορουμε να βρουμε στα φαρμακεια σε υγρη μορφή?
Topical tretinoin for hair growth promotion
Gail S. Bazzano, Ph.D., Nia Terezakis, M.D., and Wesley Galen, M.D.
New Orleans, 1_.4
Topical all-trans-retinoic acid (tretinoin) alone and in combination with 0.5%
minoxidil has been tested for the promotion of hair growth in 56 subjects
with androgenetic alopecia. After 1 year, the combination of topical
tret inoin with 0.5% minoxidil resulted in terminal hair regrowth in 66% of the
subjects studied. Tretinoin was shown to stimulate some hair regrowth in
approximately 58% of the subjects studied. One female subject with pronounced
alopecia for more than 20 years had regrowth of hair using only tretinoin
for a period of 18 months. Tretinoin has been shown to promote and regulate
cell proliferation and differentiation in the epithelium and may promote
vascular proliferation. These factors are important for hair growth promotion.
These preliminary results indicate that more work should be done on the
role of retinoids in hair growth. The synergistic effect of retineids in
combination with a low concentration of minoxidil should also be further
investigated. (J AM ACAD DERMATOL 15:880-883, 1986.)
Topical application of retinoids can produce
striking changes in epithelial structure and function.
All-trans-retinoic acid (tretinoin) is known
to alter cell proliferation and differentiation in the
epithelium ~'2 and it may promote vascular proliferation.*
These are important factors in the promotion
of hair growth.
Recent observations by dermatologists administering
isotretinoin to patients with cystic acne
indicate that retinoids may be involved in promoting
hair growth. Several dermatologists noted
that patients occasionally developed increased vellus
or lanugo facial hair in response to oral isotretinoin
therapy.t To assess the effect of tretinoin
and minoxidil and the combination of minoxidil
and retinoic acid on hair growth and regrowth, 56
Reprint requests to: Dr, Nia Terezakis, 2633 Napoleon Ave., Suite
900, New Orleans, LA 70116.
*Kligman LH; Dermal effects of topical retinoic acid io hairless mice.
Presentation before symposium entitled: Topical retinoids: An IJpdate.
April 19-20, 1986, New York, N.Y.
}'Field LM" Lanugo hair growth: A side effect of accutane--reversible?
The Schoch Letter 33:144, 1983.
880
subjects were treated in several small pilot studies
conducted between 1983 and 1986. (Two patients
are not included in the computation because they
were eliminated as a result of unusual sensitivity
to the solution. This included a possible contact
dermatitis to tretinoin.)
These pilot studies show that tretinoin promoted
hair growth when used topically (0.025% solution).
Seven of the 12 patients treated with tretinoin
had measurable, although mostly modest, hair
growth. When 0.5% minoxidil was used in combination
with 0.025% tretinoin, 24 of 36 patients
(66%) had an increase in terminal hair growth.
MATERIALS AND METHODS
Fifty-six normotensive subjects, 20 to 64 years of
age, were entered in the combined studies. The diagnosis
of androgenetic alopecia was made clinically.
Twelve subjects received a 0.025% topical tretinoin
solution, 36 received a combination of 0.025 % tretinoin
and 0.5% minoxidil solution, while three subjects received
0.5% minoxidil solution alone. The vehicle
(95% alcohol, 5% propylene glycol, and 1 mg butylated
hydroxy toulene per 100 ml) was given to five subjects.
The subjects were instructed to apply 1 ml of the
Volume 15
Number 4, Part 2
October, 1986
Tretinoin for hair growth promotion 881
Table I. Results of treatment
Treatment
No. of
patients
Placebo 5
Minoxidil 3
Tretinoin 12
Combination 36
Response
Good Moderate None
(group ,4,) (group B) (group C)
0 0 5 (100%)
0 0 3 (100%)
2 (16%) 5 (42%) 5 (42%)
16 (44%) 8 (22%) 12 (33%)
solution twice daily by dropper to the affected scalp
areas. Subjects were also advised to wear a cap for
protection from the sun or to refrain from excessive sun
exposure, and to avoid any trauma to the scalp (i.e.,
vigorous scalp scrubbing or brushing). Before treatment,
the following studies were performed on each
patient and were repeated at intervals: blood pressure,
serum chemistry tests, and complete blood counts,
weight, pulse, and electrocardiogram. Skin irritation
(erythema, scaling, and so forth) was assessed during
each follow-up visit. Photographs were taken before
and during treatment to evaluate hair growth. Hair
counts were performed initially, at monthly intervals,
or at follow-up visits.
A circular area of baldness, 1 inch in diameter, was
identified as a target at the beginning of the study.
Landmarks were noted to facilitate recognition during
subsequent evaluations. At the initial examination and
at subsequent visits, hairs in the target area were
counted. Terminal hairs were defined as thick, pigmented
hairs, comparable to those on the subject's posterior
scalp.
RESULTS
Data were analyzed to determine age of participants,
number of months in the study, baseline
number of hairs before treatment, number of hairs
at the end of therapy, change in terminal hair
count, and percentage increase in number of
terminal hairs after treatment. Subjects were
then placed into one of three designated response
groups, with percent increase in number
of terminal hairs being the primary criteria for
placement.
Participants in the "good" response group
(group A) experienced 46% to 1400% increases
in the number of hairs in the target area after treatment.
Individuals in the "moderate" response
group (group B) had a posttherapy terminal hair
increase between 21% and 45%. Participants in
the "no response" group (group C) experienced
increases below 20%. The mean amount of time
for subject participation was 10, 8, and 9 months,
respectively, for groups A, B, and C.
In 56 subjects, 48 of whom were receiving tretinoin
or the combination formulation, positive responses
were documented in more than half of the
subjects, usually within 18 months. The five patients
receiving placebo demonstrated no significant
hair growth response. Three patients receiving
the 0.5% minoxidil solution also showed no meaningful
results. Of the five men who received retinoic
acid only, two experienced some hair growth
after treatment, although the hairs were mostly of
the lanugo type.
Fifty-eight percent of subjects who received tretinoin
alone (seven women and five men) responded
positively to the treatment with mostly
moderate hair growth. Of patients treated with the
combination solution (0.5 % minoxidil and 0.025 %
retinoic acid), 66% responded positively, with
44% placed in the good response group and 22%
in the moderate response group. Of the three individuals
treated with 0.5% minoxidi], none
showed terminal hair regrowth. Nevertheless, vellus
hair growth was noted in one patient. There
was no visible hair regrowth in patients receiving
placebo. These results are summarized in Table I.
Figs. 1 to 7 represent young and middle-aged men
who showed positive responses after 4 to 18
months of treatment with the retinoic acid/minoxidil
mixture.
Examples of women who received retinoic acid
only, and in whom visible hair growth can be photographically
documented, are shown in Figs. 8
and 9. These responses occurred between 6 and
18 months of retinoic acid treatment. Some interesting
and noteworthy observations were made
about selected patients in these pilot studies: (1)
Striking results occurred in one woman using tretinoin
only: She experienced an 1100% increase
in hair growth. This 43-year-old woman had had
extensive androgenetic alopecia since she was 20
years old. Her increased hair growth took place in
18 months (Fig. 10). (2) An example of prominent
vellus hair growth in a man in response to retinoic
acid after 6 months is shown in Fig. 11. (3) Another
male patient had previously received a series
of hair transplants, but discontinued that treatment
because of poor hair growth in the transplanted
plugs. During the course of his treatment with
retinoic acid, growth was initiated in the transplanted
grafts and regular hair trimming was required.
DISCUSSION
Tretinoin has been used for 15 years in the topical
treatment of acne. While the pharmacologic
and physiologic actions of tretinoin have been under
investigation for many years,a the mechanism
of action is still not fully understood.
The penetration, permeation, absorption, and
excretion of tretinoin have been studied after topical
application of solution and ointment. 4 The
drug rapidly penetrates the horny layers, but accumulation
in the dermis is not usually observed. 4
The excretion of tretinoin and its metabolites has
been demonstrated with topical application of a
radiolabeled dose: While erythema and peeling
frequently occur with the topical use of tretinoin,
these effects are dose related in most patients, 5 and
true contact allergy to topical tretinoin is rarely
encountered.6 It has been shown that retinoic acid
binds to a cytosolic retinoic-acid-binding protein
(cRABP) and is transported to the cell nucleus.
This interaction can be shown to induce protein
synthesis as well as to increase cell turnover. 7 Effects
on membrane fluidity and lipid composition
of membranes have also been demonstrated with
retinoid treatment:
Sundelin et al 9 have shown that cRABP is abundant
in cells lining the hair follicles. This may
indicate that hair follicle cells are more susceptible
to the effects of tretinoin than are adjacent cells
that do not contain significant amounts of cRABP.
It has also been suggested by Sundelin et al 9
that the cRABP concentration in certain cells is
regulated by the availability of retinoic acid. If this
is tree, excess retinoic acid may raise cRABP
levels. Furthermore, it is known that cellular retinoic-
acid-binding protein levels decline with age
and that cRABP is found in fetal skin in amounts
that progressively decrease to adult levels.
It has recently been shown that psoriatic skin
contains ten times more cRABP than adjacent normal
skin. Because cell turnover is greatly increased
in psoriatic skin, cRABP may be active
in the mechanism by which retinoids produce their
biological effects, to
More evidence that tretinoin may be important
in hair growth comes from our recent observations
on vitamin A-deficient gerbils.* Gerbil pups born
of a vitamin A-deficient mother failed to develop
normal coats and had only sparse hair 1 month
after birth (Fig. 12). Four weeks after topical tretinoin
(0.025%) was applied to the skin of these
bald, vitamin A-deficient gerbils, a visible growth
of fur occurred (Fig. 13). This could not have been
a result of conversion to retinol (vitamin A), because
tretinoin is not converted to retinol in vivo.
This information again suggests that tretinoin may
play a significant role in hair growth.
Because retinoic acid has been shown to increase
percutaneous absorption, 11 it is possible that
in these pilot studies on androgenetic alopecia, the
increased absorption caused by retinoic acid may
have had a positive effect on the amount of minoxidil
reaching the hair follicle ceils. Studies have
shown that topically applied solutions of 2% to
5% minoxidil are effective in initiating and promoting
vellus hair growth and some terminal hair
growth on the scalps of individuals with male pattern
alopecia, t2 Minoxidil is able to produce a cos-
metically acceptable result in approximately 30%
of subjects, t3 In many subjects with alopecia, terminal
hair growth on the scalp is not sustained
with topically applied minoxidil in 2% to 5% concentrations,
and terminal hair growth did not develop
in a study of androgenetic alopecia when
individuals were treated with 1% minoxidil. 1+
The mechanism by which minoxidil exerts its
effect is believed to lie in its mitogenic activity t5
as well as in its vasodilatory properties, t6 In many
subjects, because of the advanced state of scalp
thinning and atrophy of the pilary portion of the
pilosebaceous apparatus, it has been difficult to
initiate hair growth.
Our data suggest there may be a synergism between
minoxidil and tretinoin when the substances
are combined and used topically. Retinoids can
initiate cell growth and differentiation not stimulated
by minoxidil. Likewise, minoxidil can promote
mitogenic and vasodilatory action not obtained
with the retinoids. While neither compound
alone has profound effects on advanced alopecias,
in combination the compounds may be more effective
as promoters of new hair growth in individuals
with alopecia.
Another advantage of the use of tretinoin may
also be its ability to limit the rate of hair loss and
to increase the rate of its growth, even in normal
scalps. This effect has been observed in our younger
subjects without advanced hair loss.*
Although these preliminary observations are of
considerable interest and have been confirmed by
other investigators in pilot studies, t it is premature
to make definite conclusions on the basis of 56
subjects in this survey.
It should be emphasized that this report summarizes
significant results with only 0.5% minoxidil
in combination with retinoic acid. Other
studies report that 2% to 5% minoxidil concentrations
cause a cosmetically visible hair regrowth in
30% to 40% of subjects. Our preliminary results
with only one fourth to one tenth the topical minoxidil
concentrations previously reported show
that low concentrations of minoxidil are effective
when used in combination with tretinoin. These
*Bazzano G: Unpublished data.
PSerri F, Celleno L: Personal communication.
studies suggest that mixtures of minoxidil and retinoids
may be more effective in the treatment of
alopecia than is minoxidil alone. A more extensive
survey of this type should further substantiate
these findings.
We acknowledge the contributions of Lloyd Frye,
M.D., who participated in some of the early work and
Christine Kelly, C.S.T., and Maria Lopez, M.A., who
contributed to the coordination of the studies.
REFERENCES
1. Christophers E, Wolff H: Effects of vitamin A acid in
skin: In vivo and in vitro studies. Acta Derm Venereol
[Suppl] (Stockh) 55:42-49, 1975.
2. Kaufman DG, Baker MS, Smith JM, et al: RNA metabolism
in tracheal epithelium alteration in hamsters deficient
in vitamin A. Science 177:1105-1108, 1972.
3. Heel RC, Brogden RN, Speight TM, et al: Vitamin A
acid: A review of its pharmacological properties and therapeutic
use in the topical treatment of acne vulgaris.
Drugs 14:401-419, 1977.
4. Schaefer H, Zesch A: Penetration of vitamin A acid into
human skin. Acta Derm Venereol [Suppl] (Stockh)
55:50-55, 1975.
5. Papa CM: The cutaneous safety of topical tretinoin. Acta
Derm Venereol [Suppl] (Stockh) 55:128-132, 1975.
6. Nordqvist BC, Mehn K: Allergic contact dermatitis to
retinoic acid. Contact Dermatitis 3:55-56, 1977.
7. Ong DE, Chytil F: Presence of cellular retinol and retinoic
acid-binding proteins in experimental tumors. Cancer
Lett 2:25-30, 1976.
8. Elias P: Retinoids, cancer and skin. Arch Dermatol
117:160-180, 198l.
9. Sundelin J, Busch C, Das K: Structure and tissue distribution
of some retinoic-binding proteins. J Invest Dermatol
81:59s-63s, 1983.
10. Siegenthaler G, Saurat JH, Hotz R, et al: Cellular retinoic
acid--but not cellular retinol-binding protein is elevated
in psoriatic plaques. J Invest Dermatol 86:42-45, 1986.
11. Zbinden G: Pharmacology of vitamin A acid (13-cis,
all-trans-retinoic acid). Acta Derm Venereo/ [Suppl]
(Stockh) 55:21-24, 1975.
12. Olsen EA, Weiner MS, Delong ER, et al: Topical minoxidi[
in early male pattern baldness. I AM AcaD DBRMATOL
82:90-93:, 1984.
13. De Villez RL: Topical minoxidil therapy in hereditary
androgenetic alopecia. Arch Dermatol 121:197-202,
1985.
14. Vanderveen EE, Ellis CN, Sewon K, et al: Topical minoxidil
for hair regrowth. J AM ACAD DERMATOt. 11:416-
421, 1984.
15. Cohen RL, Alves M, Weiss V, et al: Direct effects of
minoxidil on epidermal cells in culture. J Invest Dermatol
82:90-93, 1984.
16. Wester RC, Maibach HI, Guy H, et al: Minoxidil stimulates
cutaneous blood flow in human balding scalps:
Pharmacodynamics measured by laser Doppler velocimetry
and photopulse plethysmography. J Invest Dermatol
82:515-517, 1984.[/align]
Η ερευνα που διάβασα εγω ειναι η ακολουθη. Αποδεικνυει μαλλιστα πως η tretinoin εχει δραση regrowth οταν εφαρμοζεται μονη της. Ο dr Lee πουλαει διαλυμα minoxidil-tretinoin, αλλα μου φαινεται λιγο ακριβουτσικη. Τελικα ξερει κανεις αν μπορουμε να βρουμε στα φαρμακεια σε υγρη μορφή?
Topical tretinoin for hair growth promotion
Gail S. Bazzano, Ph.D., Nia Terezakis, M.D., and Wesley Galen, M.D.
New Orleans, 1_.4
Topical all-trans-retinoic acid (tretinoin) alone and in combination with 0.5%
minoxidil has been tested for the promotion of hair growth in 56 subjects
with androgenetic alopecia. After 1 year, the combination of topical
tret inoin with 0.5% minoxidil resulted in terminal hair regrowth in 66% of the
subjects studied. Tretinoin was shown to stimulate some hair regrowth in
approximately 58% of the subjects studied. One female subject with pronounced
alopecia for more than 20 years had regrowth of hair using only tretinoin
for a period of 18 months. Tretinoin has been shown to promote and regulate
cell proliferation and differentiation in the epithelium and may promote
vascular proliferation. These factors are important for hair growth promotion.
These preliminary results indicate that more work should be done on the
role of retinoids in hair growth. The synergistic effect of retineids in
combination with a low concentration of minoxidil should also be further
investigated. (J AM ACAD DERMATOL 15:880-883, 1986.)
Topical application of retinoids can produce
striking changes in epithelial structure and function.
All-trans-retinoic acid (tretinoin) is known
to alter cell proliferation and differentiation in the
epithelium ~'2 and it may promote vascular proliferation.*
These are important factors in the promotion
of hair growth.
Recent observations by dermatologists administering
isotretinoin to patients with cystic acne
indicate that retinoids may be involved in promoting
hair growth. Several dermatologists noted
that patients occasionally developed increased vellus
or lanugo facial hair in response to oral isotretinoin
therapy.t To assess the effect of tretinoin
and minoxidil and the combination of minoxidil
and retinoic acid on hair growth and regrowth, 56
Reprint requests to: Dr, Nia Terezakis, 2633 Napoleon Ave., Suite
900, New Orleans, LA 70116.
*Kligman LH; Dermal effects of topical retinoic acid io hairless mice.
Presentation before symposium entitled: Topical retinoids: An IJpdate.
April 19-20, 1986, New York, N.Y.
}'Field LM" Lanugo hair growth: A side effect of accutane--reversible?
The Schoch Letter 33:144, 1983.
880
subjects were treated in several small pilot studies
conducted between 1983 and 1986. (Two patients
are not included in the computation because they
were eliminated as a result of unusual sensitivity
to the solution. This included a possible contact
dermatitis to tretinoin.)
These pilot studies show that tretinoin promoted
hair growth when used topically (0.025% solution).
Seven of the 12 patients treated with tretinoin
had measurable, although mostly modest, hair
growth. When 0.5% minoxidil was used in combination
with 0.025% tretinoin, 24 of 36 patients
(66%) had an increase in terminal hair growth.
MATERIALS AND METHODS
Fifty-six normotensive subjects, 20 to 64 years of
age, were entered in the combined studies. The diagnosis
of androgenetic alopecia was made clinically.
Twelve subjects received a 0.025% topical tretinoin
solution, 36 received a combination of 0.025 % tretinoin
and 0.5% minoxidil solution, while three subjects received
0.5% minoxidil solution alone. The vehicle
(95% alcohol, 5% propylene glycol, and 1 mg butylated
hydroxy toulene per 100 ml) was given to five subjects.
The subjects were instructed to apply 1 ml of the
Volume 15
Number 4, Part 2
October, 1986
Tretinoin for hair growth promotion 881
Table I. Results of treatment
Treatment
No. of
patients
Placebo 5
Minoxidil 3
Tretinoin 12
Combination 36
Response
Good Moderate None
(group ,4,) (group B) (group C)
0 0 5 (100%)
0 0 3 (100%)
2 (16%) 5 (42%) 5 (42%)
16 (44%) 8 (22%) 12 (33%)
solution twice daily by dropper to the affected scalp
areas. Subjects were also advised to wear a cap for
protection from the sun or to refrain from excessive sun
exposure, and to avoid any trauma to the scalp (i.e.,
vigorous scalp scrubbing or brushing). Before treatment,
the following studies were performed on each
patient and were repeated at intervals: blood pressure,
serum chemistry tests, and complete blood counts,
weight, pulse, and electrocardiogram. Skin irritation
(erythema, scaling, and so forth) was assessed during
each follow-up visit. Photographs were taken before
and during treatment to evaluate hair growth. Hair
counts were performed initially, at monthly intervals,
or at follow-up visits.
A circular area of baldness, 1 inch in diameter, was
identified as a target at the beginning of the study.
Landmarks were noted to facilitate recognition during
subsequent evaluations. At the initial examination and
at subsequent visits, hairs in the target area were
counted. Terminal hairs were defined as thick, pigmented
hairs, comparable to those on the subject's posterior
scalp.
RESULTS
Data were analyzed to determine age of participants,
number of months in the study, baseline
number of hairs before treatment, number of hairs
at the end of therapy, change in terminal hair
count, and percentage increase in number of
terminal hairs after treatment. Subjects were
then placed into one of three designated response
groups, with percent increase in number
of terminal hairs being the primary criteria for
placement.
Participants in the "good" response group
(group A) experienced 46% to 1400% increases
in the number of hairs in the target area after treatment.
Individuals in the "moderate" response
group (group B) had a posttherapy terminal hair
increase between 21% and 45%. Participants in
the "no response" group (group C) experienced
increases below 20%. The mean amount of time
for subject participation was 10, 8, and 9 months,
respectively, for groups A, B, and C.
In 56 subjects, 48 of whom were receiving tretinoin
or the combination formulation, positive responses
were documented in more than half of the
subjects, usually within 18 months. The five patients
receiving placebo demonstrated no significant
hair growth response. Three patients receiving
the 0.5% minoxidil solution also showed no meaningful
results. Of the five men who received retinoic
acid only, two experienced some hair growth
after treatment, although the hairs were mostly of
the lanugo type.
Fifty-eight percent of subjects who received tretinoin
alone (seven women and five men) responded
positively to the treatment with mostly
moderate hair growth. Of patients treated with the
combination solution (0.5 % minoxidil and 0.025 %
retinoic acid), 66% responded positively, with
44% placed in the good response group and 22%
in the moderate response group. Of the three individuals
treated with 0.5% minoxidi], none
showed terminal hair regrowth. Nevertheless, vellus
hair growth was noted in one patient. There
was no visible hair regrowth in patients receiving
placebo. These results are summarized in Table I.
Figs. 1 to 7 represent young and middle-aged men
who showed positive responses after 4 to 18
months of treatment with the retinoic acid/minoxidil
mixture.
Examples of women who received retinoic acid
only, and in whom visible hair growth can be photographically
documented, are shown in Figs. 8
and 9. These responses occurred between 6 and
18 months of retinoic acid treatment. Some interesting
and noteworthy observations were made
about selected patients in these pilot studies: (1)
Striking results occurred in one woman using tretinoin
only: She experienced an 1100% increase
in hair growth. This 43-year-old woman had had
extensive androgenetic alopecia since she was 20
years old. Her increased hair growth took place in
18 months (Fig. 10). (2) An example of prominent
vellus hair growth in a man in response to retinoic
acid after 6 months is shown in Fig. 11. (3) Another
male patient had previously received a series
of hair transplants, but discontinued that treatment
because of poor hair growth in the transplanted
plugs. During the course of his treatment with
retinoic acid, growth was initiated in the transplanted
grafts and regular hair trimming was required.
DISCUSSION
Tretinoin has been used for 15 years in the topical
treatment of acne. While the pharmacologic
and physiologic actions of tretinoin have been under
investigation for many years,a the mechanism
of action is still not fully understood.
The penetration, permeation, absorption, and
excretion of tretinoin have been studied after topical
application of solution and ointment. 4 The
drug rapidly penetrates the horny layers, but accumulation
in the dermis is not usually observed. 4
The excretion of tretinoin and its metabolites has
been demonstrated with topical application of a
radiolabeled dose: While erythema and peeling
frequently occur with the topical use of tretinoin,
these effects are dose related in most patients, 5 and
true contact allergy to topical tretinoin is rarely
encountered.6 It has been shown that retinoic acid
binds to a cytosolic retinoic-acid-binding protein
(cRABP) and is transported to the cell nucleus.
This interaction can be shown to induce protein
synthesis as well as to increase cell turnover. 7 Effects
on membrane fluidity and lipid composition
of membranes have also been demonstrated with
retinoid treatment:
Sundelin et al 9 have shown that cRABP is abundant
in cells lining the hair follicles. This may
indicate that hair follicle cells are more susceptible
to the effects of tretinoin than are adjacent cells
that do not contain significant amounts of cRABP.
It has also been suggested by Sundelin et al 9
that the cRABP concentration in certain cells is
regulated by the availability of retinoic acid. If this
is tree, excess retinoic acid may raise cRABP
levels. Furthermore, it is known that cellular retinoic-
acid-binding protein levels decline with age
and that cRABP is found in fetal skin in amounts
that progressively decrease to adult levels.
It has recently been shown that psoriatic skin
contains ten times more cRABP than adjacent normal
skin. Because cell turnover is greatly increased
in psoriatic skin, cRABP may be active
in the mechanism by which retinoids produce their
biological effects, to
More evidence that tretinoin may be important
in hair growth comes from our recent observations
on vitamin A-deficient gerbils.* Gerbil pups born
of a vitamin A-deficient mother failed to develop
normal coats and had only sparse hair 1 month
after birth (Fig. 12). Four weeks after topical tretinoin
(0.025%) was applied to the skin of these
bald, vitamin A-deficient gerbils, a visible growth
of fur occurred (Fig. 13). This could not have been
a result of conversion to retinol (vitamin A), because
tretinoin is not converted to retinol in vivo.
This information again suggests that tretinoin may
play a significant role in hair growth.
Because retinoic acid has been shown to increase
percutaneous absorption, 11 it is possible that
in these pilot studies on androgenetic alopecia, the
increased absorption caused by retinoic acid may
have had a positive effect on the amount of minoxidil
reaching the hair follicle ceils. Studies have
shown that topically applied solutions of 2% to
5% minoxidil are effective in initiating and promoting
vellus hair growth and some terminal hair
growth on the scalps of individuals with male pattern
alopecia, t2 Minoxidil is able to produce a cos-
metically acceptable result in approximately 30%
of subjects, t3 In many subjects with alopecia, terminal
hair growth on the scalp is not sustained
with topically applied minoxidil in 2% to 5% concentrations,
and terminal hair growth did not develop
in a study of androgenetic alopecia when
individuals were treated with 1% minoxidil. 1+
The mechanism by which minoxidil exerts its
effect is believed to lie in its mitogenic activity t5
as well as in its vasodilatory properties, t6 In many
subjects, because of the advanced state of scalp
thinning and atrophy of the pilary portion of the
pilosebaceous apparatus, it has been difficult to
initiate hair growth.
Our data suggest there may be a synergism between
minoxidil and tretinoin when the substances
are combined and used topically. Retinoids can
initiate cell growth and differentiation not stimulated
by minoxidil. Likewise, minoxidil can promote
mitogenic and vasodilatory action not obtained
with the retinoids. While neither compound
alone has profound effects on advanced alopecias,
in combination the compounds may be more effective
as promoters of new hair growth in individuals
with alopecia.
Another advantage of the use of tretinoin may
also be its ability to limit the rate of hair loss and
to increase the rate of its growth, even in normal
scalps. This effect has been observed in our younger
subjects without advanced hair loss.*
Although these preliminary observations are of
considerable interest and have been confirmed by
other investigators in pilot studies, t it is premature
to make definite conclusions on the basis of 56
subjects in this survey.
It should be emphasized that this report summarizes
significant results with only 0.5% minoxidil
in combination with retinoic acid. Other
studies report that 2% to 5% minoxidil concentrations
cause a cosmetically visible hair regrowth in
30% to 40% of subjects. Our preliminary results
with only one fourth to one tenth the topical minoxidil
concentrations previously reported show
that low concentrations of minoxidil are effective
when used in combination with tretinoin. These
*Bazzano G: Unpublished data.
PSerri F, Celleno L: Personal communication.
studies suggest that mixtures of minoxidil and retinoids
may be more effective in the treatment of
alopecia than is minoxidil alone. A more extensive
survey of this type should further substantiate
these findings.
We acknowledge the contributions of Lloyd Frye,
M.D., who participated in some of the early work and
Christine Kelly, C.S.T., and Maria Lopez, M.A., who
contributed to the coordination of the studies.
REFERENCES
1. Christophers E, Wolff H: Effects of vitamin A acid in
skin: In vivo and in vitro studies. Acta Derm Venereol
[Suppl] (Stockh) 55:42-49, 1975.
2. Kaufman DG, Baker MS, Smith JM, et al: RNA metabolism
in tracheal epithelium alteration in hamsters deficient
in vitamin A. Science 177:1105-1108, 1972.
3. Heel RC, Brogden RN, Speight TM, et al: Vitamin A
acid: A review of its pharmacological properties and therapeutic
use in the topical treatment of acne vulgaris.
Drugs 14:401-419, 1977.
4. Schaefer H, Zesch A: Penetration of vitamin A acid into
human skin. Acta Derm Venereol [Suppl] (Stockh)
55:50-55, 1975.
5. Papa CM: The cutaneous safety of topical tretinoin. Acta
Derm Venereol [Suppl] (Stockh) 55:128-132, 1975.
6. Nordqvist BC, Mehn K: Allergic contact dermatitis to
retinoic acid. Contact Dermatitis 3:55-56, 1977.
7. Ong DE, Chytil F: Presence of cellular retinol and retinoic
acid-binding proteins in experimental tumors. Cancer
Lett 2:25-30, 1976.
8. Elias P: Retinoids, cancer and skin. Arch Dermatol
117:160-180, 198l.
9. Sundelin J, Busch C, Das K: Structure and tissue distribution
of some retinoic-binding proteins. J Invest Dermatol
81:59s-63s, 1983.
10. Siegenthaler G, Saurat JH, Hotz R, et al: Cellular retinoic
acid--but not cellular retinol-binding protein is elevated
in psoriatic plaques. J Invest Dermatol 86:42-45, 1986.
11. Zbinden G: Pharmacology of vitamin A acid (13-cis,
all-trans-retinoic acid). Acta Derm Venereo/ [Suppl]
(Stockh) 55:21-24, 1975.
12. Olsen EA, Weiner MS, Delong ER, et al: Topical minoxidi[
in early male pattern baldness. I AM AcaD DBRMATOL
82:90-93:, 1984.
13. De Villez RL: Topical minoxidil therapy in hereditary
androgenetic alopecia. Arch Dermatol 121:197-202,
1985.
14. Vanderveen EE, Ellis CN, Sewon K, et al: Topical minoxidil
for hair regrowth. J AM ACAD DERMATOt. 11:416-
421, 1984.
15. Cohen RL, Alves M, Weiss V, et al: Direct effects of
minoxidil on epidermal cells in culture. J Invest Dermatol
82:90-93, 1984.
16. Wester RC, Maibach HI, Guy H, et al: Minoxidil stimulates
cutaneous blood flow in human balding scalps:
Pharmacodynamics measured by laser Doppler velocimetry
and photopulse plethysmography. J Invest Dermatol
82:515-517, 1984.[/align]
Απ: Δυναμωστε το Regaine η αποιαδηποτε μινοξιδιλη σας απλα
Γιατί απαραίτητα σε υγρή μορφή και όχι σε μορφή κρέμας;; Μέλος εδώ (azyx) έχει δοκιμάσει με κρέμα - χωριστά με μινοξιδίλη - και έχει εντυπωσιακά αποτελέσματα! δες το blog του http://andreaszam.blogspot.com/
Γιατί απαραίτητα σε υγρή μορφή και όχι σε μορφή κρέμας;; Μέλος εδώ (azyx) έχει δοκιμάσει με κρέμα - χωριστά με μινοξιδίλη - και έχει εντυπωσιακά αποτελέσματα! δες το blog του http://andreaszam.blogspot.com/
Απ: Δυναμωστε το Regaine η αποιαδηποτε μινοξιδιλη σας απλα
[/quote]
True!!
γιατί όχι τότε εφαρμογή της λίγες ώρες πριν το λούσιμο;
Εαν δεν κανω λαθος ο azyx την χρησιμοποιεί σε γυμνη περιοχη (κροταφοι). Αναμεσα στα μαλια φανταζομαι πως θα ειναι δυσκολη η εφαρμογη της κρεμας και θα τα λαδωνει πολυ ασχημαZAF είπε:
[/quote]
True!!
γιατί όχι τότε εφαρμογή της λίγες ώρες πριν το λούσιμο;
spartangr01
New Member
Απ: Δυναμωστε το Regaine η αποιαδηποτε μινοξιδιλη σας απλα
εγω εχω ριξει καποια μγ κρεμας αιρολ μεσα στην μινοξ
δεν εκανα καλα?
και κατι ακομα πιστευετε οτι το παραπανω μειγμα χρειαζεται ψυγειο?
ευχαριστω παιδια
εγω εχω ριξει καποια μγ κρεμας αιρολ μεσα στην μινοξ
δεν εκανα καλα?
και κατι ακομα πιστευετε οτι το παραπανω μειγμα χρειαζεται ψυγειο?
ευχαριστω παιδια
Παναγιωτης
Μέλος του προσωπικού
Απ: Δυναμωστε το Regaine η αποιαδηποτε μινοξιδιλη σας απλα
οχι δεν εκανες καλα οχι την την δραστικη ουσια που εχει το airol
αλλα γιατι το airol ειναι κρεμα και δεν αναμυγνυετε σωστα
καλυτερα ειτε πριν ειτε μερα η χρηση του airol
και οχι μαζι με την μινοξιδιλη
οχι δεν χρειαζετε ψυγειο
αλλα μην το εκθετεις σε θερμοκρασιες υψηλες κοντα στους 20 και ειναι καλα
spartangr01 είπε:
οχι δεν εκανες καλα οχι την την δραστικη ουσια που εχει το airol
αλλα γιατι το airol ειναι κρεμα και δεν αναμυγνυετε σωστα
καλυτερα ειτε πριν ειτε μερα η χρηση του airol
και οχι μαζι με την μινοξιδιλη
οχι δεν χρειαζετε ψυγειο
αλλα μην το εκθετεις σε θερμοκρασιες υψηλες κοντα στους 20 και ειναι καλα
Παναγιωτης
Μέλος του προσωπικού
Απ: Δυναμωστε το Regaine η αποιαδηποτε μινοξιδιλη σας απλα
κορτιζονούχο ειναι φιλε
κορτιζονούχο ειναι φιλε
Παρακαλώ συνδεθείτε ή εγγραφείτε για να απενεργοποιήσετε τις διαφημίσεις.
spartangr01
New Member
Απ: Δυναμωστε το Regaine η αποιαδηποτε μινοξιδιλη σας απλα
οχι δεν εκανες καλα οχι την την δραστικη ουσια που εχει το airol
αλλα γιατι το airol ειναι κρεμα και δεν αναμυγνυετε σωστα
καλυτερα ειτε πριν ειτε μερα η χρηση του airol
και οχι μαζι με την μινοξιδιλη
οχι δεν χρειαζετε ψυγειο
αλλα μην το εκθετεις σε θερμοκρασιες υψηλες κοντα στους 20 και ειναι καλα
[/quote]
σ ευχαριστω Παναγιωτη
πως μπορω ομως να προσθεσω τρετινοιν αλλιως?
Παναγιωτης είπε:
οχι δεν εκανες καλα οχι την την δραστικη ουσια που εχει το airol
αλλα γιατι το airol ειναι κρεμα και δεν αναμυγνυετε σωστα
καλυτερα ειτε πριν ειτε μερα η χρηση του airol
και οχι μαζι με την μινοξιδιλη
οχι δεν χρειαζετε ψυγειο
αλλα μην το εκθετεις σε θερμοκρασιες υψηλες κοντα στους 20 και ειναι καλα
[/quote]
σ ευχαριστω Παναγιωτη
πως μπορω ομως να προσθεσω τρετινοιν αλλιως?
Παναγιωτης
Μέλος του προσωπικού
Απ: Δυναμωστε το Regaine η αποιαδηποτε μινοξιδιλη σας απλα
spartangr01
θα πρεπει να την βρεις σε αλλη μορφη την ουσια που ψαχνεις
spartangr01
θα πρεπει να την βρεις σε αλλη μορφη την ουσια που ψαχνεις
mindtrapper
Member
Απ: Δυναμωστε το Regaine η αποιαδηποτε μινοξιδιλη σας απλα
Σκέφτομαι τώρα τελευταία να ενισχύσω λίγο τη μινόξ (εδώ και ένα μήνα την ξεκίνησα πάλι, έπαιρνα παλιά όταν είχα ακόμα πολύ μαλλί). Βάζω 2 φώτο για να δείτε κατάσταση. Δεν ξέρω γιατί είχα ερεθισμό στο κεφάλι εκείνη τη μέρα, μάλλον επειδή είχα ιδρώσει λίγο από τη ζέστη και το περπάτημα (ρωτήστε τον comb
). Τώρα δεν βλέπω ερεθισμό πάντως.
Θα βοηθήσει στο να δω ικανοποιητικό αποτέλεσμα αν προσθέσω σε ένα μπουκάλι μινόξ:
- 6ml απόσταγμα πράσινου τσαγιού
- 5 κάψουλες avodart
- 4 από αυτά: http://www.pharmacy4u.gr/product_info.php?products_id=3092&language=gr&sesId=34b522f045a622d6f8f4d4dfd7ceb897
Επίσης έχω κάτι χάπια καφεΐνης 200mg. Να ρίξω και από αυτά κανένα μέσα και αν πόσα; Ξέρουμε αν βοηθάει μαζί με μινόξ ή εμποδίζει; Έχω διαβάσει αυτό: http://www.hairlossgr.com/forum/index.php/topic,1614.0.html αλλά ρωτάω για να είμαι σίγουρος.
Παίζουν sides με αυτές τις ποσότητες;
Θα δώσει τίποτα πιστεύετε στην περίπτωση μου; Δηλαδή αρκετή επανέκφυση ώστε να έχω αρκετή κάλυψη να τα μακρύνω χωρίς να φαίνονται χάλια, αυτό εννοώ. Ή κάνω όνειρα;
Thanks.
ΥΓ. Τι NW είμαι; 4 ή 5; Για να θεωρηθεί 5 δεν θα έπρεπε να ήταν γυμνή τελείως η περιοχή;
Σκέφτομαι τώρα τελευταία να ενισχύσω λίγο τη μινόξ (εδώ και ένα μήνα την ξεκίνησα πάλι, έπαιρνα παλιά όταν είχα ακόμα πολύ μαλλί). Βάζω 2 φώτο για να δείτε κατάσταση. Δεν ξέρω γιατί είχα ερεθισμό στο κεφάλι εκείνη τη μέρα, μάλλον επειδή είχα ιδρώσει λίγο από τη ζέστη και το περπάτημα (ρωτήστε τον comb
). Τώρα δεν βλέπω ερεθισμό πάντως.Θα βοηθήσει στο να δω ικανοποιητικό αποτέλεσμα αν προσθέσω σε ένα μπουκάλι μινόξ:
- 6ml απόσταγμα πράσινου τσαγιού
- 5 κάψουλες avodart
- 4 από αυτά: http://www.pharmacy4u.gr/product_info.php?products_id=3092&language=gr&sesId=34b522f045a622d6f8f4d4dfd7ceb897
Επίσης έχω κάτι χάπια καφεΐνης 200mg. Να ρίξω και από αυτά κανένα μέσα και αν πόσα; Ξέρουμε αν βοηθάει μαζί με μινόξ ή εμποδίζει; Έχω διαβάσει αυτό: http://www.hairlossgr.com/forum/index.php/topic,1614.0.html αλλά ρωτάω για να είμαι σίγουρος.
Παίζουν sides με αυτές τις ποσότητες;
Θα δώσει τίποτα πιστεύετε στην περίπτωση μου; Δηλαδή αρκετή επανέκφυση ώστε να έχω αρκετή κάλυψη να τα μακρύνω χωρίς να φαίνονται χάλια, αυτό εννοώ. Ή κάνω όνειρα;
Thanks.
ΥΓ. Τι NW είμαι; 4 ή 5; Για να θεωρηθεί 5 δεν θα έπρεπε να ήταν γυμνή τελείως η περιοχή;
Συνημμένα
kapa
Μέλος του προσωπικού
Απ: Δυναμωστε το Regaine η αποιαδηποτε μινοξιδιλη σας απλα
Επίσης έχω κάτι χάπια καφεΐνης 200mg. Να ρίξω και από αυτά κανένα μέσα και αν πόσα; Ξέρουμε αν βοηθάει μαζί με μινόξ ή εμποδίζει;
[/quote]
η καφεινη μπλοκαρει την μινοξ,σαν ουσιες ειναι αντιθετες η μινοξιδιλη κανει κατακρατηση και η καφεινη διουριση
Επίσης έχω κάτι χάπια καφεΐνης 200mg. Να ρίξω και από αυτά κανένα μέσα και αν πόσα; Ξέρουμε αν βοηθάει μαζί με μινόξ ή εμποδίζει;
[/quote]
η καφεινη μπλοκαρει την μινοξ,σαν ουσιες ειναι αντιθετες η μινοξιδιλη κανει κατακρατηση και η καφεινη διουριση
mindtrapper
Member
Απ: Δυναμωστε το Regaine η αποιαδηποτε μινοξιδιλη σας απλα
http://www.lipoxidil.com/site/lipoxidil.php - "Next ingredient is caffeine. Caffeine counteracts the growth inhibitory effects of testosterone. Growth suppression caused by DHT was ex-vivo completely neutralized by caffeine 0.005 %. Further caffeine significantly stimulated hair growth."
http://en.wikipedia.org/wiki/Baldness_treatments#Caffeine - Δε λέει μαζί με μινόξ, αλλά μόνη της.
Επίσης το ότι η μινόξ ανοίγει τα αγγεία και η καφεΐνη τα κλείνει δε σημαίνει ότι δεν δουλεύουν μαζί. Εκτός αν το ΜΟΝΟ που κάνει η μινόξ είναι να ανοίγει τα αγγεία. Δεν πιστεύω ότι αυτό είναι αλήθεια, γιατί τότε θα μπορούσαμε να βγάλουμε μαλλιά αν κυκλοφορούσαμε με μια ζεστή πετσέτα στο κεφάλι για ένα χρόνο (χμμμμμμ....).
Ίσως το ότι η καφεΐνη κάνει αγγειοσυστολή βοηθάει και ενάντια της DHT στους θύλακες; Δεν πιστεύω ότι η απάντηση είναι τόσο απλή όσο "το ένα κάνει αυτό και το άλλο αυτό, τέλος". Και αυτό επειδή δεν ξέρουμε ακριβώς πως δρα η μινόξ και προσφέρει τριχοφυΐα. Πάντως ακόμα και αν το μόνο που κάνει είναι αγγειοδιαστολή, ίσως μια μικρή ποσότητα καφεΐνης να βοηθούσε χωρίς να ακυρώνει τη δράση της;
Δεν ξέρω με την αδενοσίνη τι γίνεται όμως, η καφεΐνη είναι ανταγωνιστής των υποδοχέων της. Αν ο μηχανισμός δράσης της μινόξ στηρίζεται αποκλειστικά στην αδενοσίνη τότε ΣΙΓΟΥΡΑ δεν πρέπει να μπουν μαζί. Εκτός αν συμπληρώσουμε αδενοσίνη τοπικά. Δεν είναι πρόβλημα όμως αυτό και με το εκχύλισμα πράσινου τσαγιού που έχει προταθεί εδώ; Δεν περιέχει καφεΐνη και αυτό;
Έχει ενδιαφέρον το θέμα.
kapamarou είπε:
η καφεινη μπλοκαρει την μινοξ,σαν ουσιες ειναι αντιθετες η μινοξιδιλη κανει κατακρατηση και η καφεινη διουριση
http://www.lipoxidil.com/site/lipoxidil.php - "Next ingredient is caffeine. Caffeine counteracts the growth inhibitory effects of testosterone. Growth suppression caused by DHT was ex-vivo completely neutralized by caffeine 0.005 %. Further caffeine significantly stimulated hair growth."
http://en.wikipedia.org/wiki/Baldness_treatments#Caffeine - Δε λέει μαζί με μινόξ, αλλά μόνη της.
Επίσης το ότι η μινόξ ανοίγει τα αγγεία και η καφεΐνη τα κλείνει δε σημαίνει ότι δεν δουλεύουν μαζί. Εκτός αν το ΜΟΝΟ που κάνει η μινόξ είναι να ανοίγει τα αγγεία. Δεν πιστεύω ότι αυτό είναι αλήθεια, γιατί τότε θα μπορούσαμε να βγάλουμε μαλλιά αν κυκλοφορούσαμε με μια ζεστή πετσέτα στο κεφάλι για ένα χρόνο (χμμμμμμ....
). Ίσως το ότι η καφεΐνη κάνει αγγειοσυστολή βοηθάει και ενάντια της DHT στους θύλακες; Δεν πιστεύω ότι η απάντηση είναι τόσο απλή όσο "το ένα κάνει αυτό και το άλλο αυτό, τέλος". Και αυτό επειδή δεν ξέρουμε ακριβώς πως δρα η μινόξ και προσφέρει τριχοφυΐα. Πάντως ακόμα και αν το μόνο που κάνει είναι αγγειοδιαστολή, ίσως μια μικρή ποσότητα καφεΐνης να βοηθούσε χωρίς να ακυρώνει τη δράση της;
Δεν ξέρω με την αδενοσίνη τι γίνεται όμως, η καφεΐνη είναι ανταγωνιστής των υποδοχέων της. Αν ο μηχανισμός δράσης της μινόξ στηρίζεται αποκλειστικά στην αδενοσίνη τότε ΣΙΓΟΥΡΑ δεν πρέπει να μπουν μαζί. Εκτός αν συμπληρώσουμε αδενοσίνη τοπικά. Δεν είναι πρόβλημα όμως αυτό και με το εκχύλισμα πράσινου τσαγιού που έχει προταθεί εδώ; Δεν περιέχει καφεΐνη και αυτό;
Έχει ενδιαφέρον το θέμα.
kapa
Μέλος του προσωπικού
Απ: Δυναμωστε το Regaine η αποιαδηποτε μινοξιδιλη σας απλα
http://www.lipoxidil.com/site/lipoxidil.php - "Next ingredient is caffeine. Caffeine counteracts the growth inhibitory effects of testosterone. Growth suppression caused by DHT was ex-vivo completely neutralized by caffeine 0.005 %. Further caffeine significantly stimulated hair growth."
http://en.wikipedia.org/wiki/Baldness_treatments#Caffeine - Δε λέει μαζί με μινόξ, αλλά μόνη της.
Επίσης το ότι η μινόξ ανοίγει τα αγγεία και η καφεΐνη τα κλείνει δε σημαίνει ότι δεν δουλεύουν μαζί. Εκτός αν το ΜΟΝΟ που κάνει η μινόξ είναι να ανοίγει τα αγγεία. Δεν πιστεύω ότι αυτό είναι αλήθεια, γιατί τότε θα μπορούσαμε να βγάλουμε μαλλιά αν κυκλοφορούσαμε με μια ζεστή πετσέτα στο κεφάλι για ένα χρόνο (χμμμμμμ....).
Ίσως το ότι η καφεΐνη κάνει αγγειοσυστολή βοηθάει και ενάντια της DHT στους θύλακες; Δεν πιστεύω ότι η απάντηση είναι τόσο απλή όσο "το ένα κάνει αυτό και το άλλο αυτό, τέλος". Και αυτό επειδή δεν ξέρουμε ακριβώς πως δρα η μινόξ και προσφέρει τριχοφυΐα. Πάντως ακόμα και αν το μόνο που κάνει είναι αγγειοδιαστολή, ίσως μια μικρή ποσότητα καφεΐνης να βοηθούσε χωρίς να ακυρώνει τη δράση της;
Έχει ενδιαφέρον το θέμα.
[/quote]
παντως ο ποιο δυνατος συνδιασμος ειναι μινοξ και airol,απο οσο βλεπω τους χρηστες και τις ερευνες,οταν ξαναξεκινησω μινοξ θα τα συνδιασω
mindtrapper είπε:
η καφεινη μπλοκαρει την μινοξ,σαν ουσιες ειναι αντιθετες η μινοξιδιλη κανει κατακρατηση και η καφεινη διουριση
http://www.lipoxidil.com/site/lipoxidil.php - "Next ingredient is caffeine. Caffeine counteracts the growth inhibitory effects of testosterone. Growth suppression caused by DHT was ex-vivo completely neutralized by caffeine 0.005 %. Further caffeine significantly stimulated hair growth."
http://en.wikipedia.org/wiki/Baldness_treatments#Caffeine - Δε λέει μαζί με μινόξ, αλλά μόνη της.
Επίσης το ότι η μινόξ ανοίγει τα αγγεία και η καφεΐνη τα κλείνει δε σημαίνει ότι δεν δουλεύουν μαζί. Εκτός αν το ΜΟΝΟ που κάνει η μινόξ είναι να ανοίγει τα αγγεία. Δεν πιστεύω ότι αυτό είναι αλήθεια, γιατί τότε θα μπορούσαμε να βγάλουμε μαλλιά αν κυκλοφορούσαμε με μια ζεστή πετσέτα στο κεφάλι για ένα χρόνο (χμμμμμμ....
). Ίσως το ότι η καφεΐνη κάνει αγγειοσυστολή βοηθάει και ενάντια της DHT στους θύλακες; Δεν πιστεύω ότι η απάντηση είναι τόσο απλή όσο "το ένα κάνει αυτό και το άλλο αυτό, τέλος". Και αυτό επειδή δεν ξέρουμε ακριβώς πως δρα η μινόξ και προσφέρει τριχοφυΐα. Πάντως ακόμα και αν το μόνο που κάνει είναι αγγειοδιαστολή, ίσως μια μικρή ποσότητα καφεΐνης να βοηθούσε χωρίς να ακυρώνει τη δράση της;
Έχει ενδιαφέρον το θέμα.
[/quote]
παντως ο ποιο δυνατος συνδιασμος ειναι μινοξ και airol,απο οσο βλεπω τους χρηστες και τις ερευνες,οταν ξαναξεκινησω μινοξ θα τα συνδιασω
mindtrapper
Member
Απ: Δυναμωστε το Regaine η αποιαδηποτε μινοξιδιλη σας απλα
Συμπλήρωσα ενώ έγραφες και για το εκχύλισμα πράσινου τσαγιού που έχει προταθεί εδώ. Περιέχει καφείνη και αυτό.
Έστω, μπορεί να πει κάποιος αν θα βοηθήσουν οι προσθήκες που είπα ακόμα και χωρίς το πράσινο τσάι και την καφεΐνη;
Συμπλήρωσα ενώ έγραφες και για το εκχύλισμα πράσινου τσαγιού που έχει προταθεί εδώ. Περιέχει καφείνη και αυτό.
Έστω, μπορεί να πει κάποιος αν θα βοηθήσουν οι προσθήκες που είπα ακόμα και χωρίς το πράσινο τσάι και την καφεΐνη;
Παναγιωτης
Μέλος του προσωπικού
Απ: Δυναμωστε το Regaine η αποιαδηποτε μινοξιδιλη σας απλα
για την αλληλεπιδραση εχω γραψει εγω
οπως και το θεμα ενδυναμωσης την μινοξ
ειναι καπως παλιο το θεμα
και απο τοτε εχουν αλλαξει πολλα
φυσικα και μην βαλεις καφεινη μεσα
το πρασινο τσαι και αυτα ειναι καλουτσικα αλλα light
οταν παρω καμια αδεια θα σας βαλω ενα ΝΕΟ τοπικο μινοξιδιλης που θα τα Σπασει ολα
οποτε αυτο πλεον θα ειναι παραλθνον
για την αλληλεπιδραση εχω γραψει εγω
οπως και το θεμα ενδυναμωσης την μινοξ
ειναι καπως παλιο το θεμα
και απο τοτε εχουν αλλαξει πολλα
φυσικα και μην βαλεις καφεινη μεσα
το πρασινο τσαι και αυτα ειναι καλουτσικα αλλα light
οταν παρω καμια αδεια θα σας βαλω ενα ΝΕΟ τοπικο μινοξιδιλης που θα τα Σπασει ολα
οποτε αυτο πλεον θα ειναι παραλθνον
- Κατάσταση