RE: Το Epa εμποδίζει την PGD2 και τη τριχόπτωση
giannis25 είπε:
http://m.advances.nutrition.org/content/2/4/304.full
Πολύ ενδιαφέρον αυτή η παράγραφος, μιας και έχουμε αναφέρει πως ένα υποξικό περιβάλλον, ευνοεί τη μετατροπή της τεστοστερόνης σε dht έναντι των οιστρογόνων.
Rodent studies show that
increasing adipose tissue mass without a similar magnitude increase in supporting vasculature could lead to tissue hypoxia, triggering the expression of hypoxia-inducible factor-1 and inflammatory genes (26). Similarly, oxygen partial pressure in subcutaneous adipose tissue negatively correlates with adiposity in humans (27). Thus, hypoxia could be a trigger for adipose tissue inflammation. Both animal and human studies support the role of adipose tissue endoplasmic reticulum (ER) stress as another key elicitor for subsequent inflammation in obesity (28–31).
Although there is evidence that adipose tissue expansion per se is an important initiator of the inflammatory processes during the development of obesity, other lines of evidence suggest that type of dietary fat is also an important factor in triggering this process.
For example, the NF-κB pathway in the visceral adipose tissue is activated 2 h after consumption of a meal rich in SFA in rodents (32).