Απ: Μελέτη για θεραπεία με οξυζενέ απο Κινέζικο πανεπι
είπα και εγώ ακουαφόρτε ρίξαν στα ποντίκια ......
μία σύνδεση που βρήκα .....
. In conclusion, H2O2 increases eNOS expression through transcriptional and post-transcriptional mechanisms. Although H2O2 does not mediate shear-dependent eNOS regulation, it is likely to be involved in regulation of eNOS expression in response to other physiological and/or pathophysiological stimuli.
http://circres.ahajournals.org/cgi/content/abstract/86/3/347
Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species
Nitric oxide, NO, which is generated by various components of the immune system, has been presumed to be cytotoxic. However, NO has been proposed to be protective against cellular damage resulting during ischemia reperfusion. Along with NO there is often concomitant formation of superoxide/hydrogen peroxide, and hence a synergistic relationship between the cytotoxic effects of nitric oxide and these active oxygen species is frequently assumed. To study more carefully the potential synergy between NO and active oxygen species in mammalian cell cytotoxicity, we utilized either hypoxanthine/xanthine cell cytotoxicity, we utilized either hypoxanthine/xanthine oxidase (a system that generates superoxide/hydrogen peroxide) or hydrogen peroxide itself. NO generation was accomplished by the use of a class of compounds known as "NONOates," which release NO at ambient temperatures without the requirement of enzyme activation or biotransformation. When Chinese hamster lung fibroblasts (V79 cells) were exposed to hypoxanthine/xanthine oxidase for various times or increasing amounts of hydrogen peroxide, there was a dose-dependent decrease in survival of V79 cells as measured by clonogenic assays.
However, in the presence of NO released from (C2H5)2N[N(O)NO]-Na+ (DEA/NO), the cytotoxicity resulting from superoxide or hydrogen peroxide was markedly abrogated. Similarly, primary cultures of rat mesencephalic dopaminergic cells exposed either to hydrogen peroxide or to hypoxanthine/xanthine oxidase resulted in the degradation of the dopamine uptake and release mechanism. As was observed in the case of the V79 cells, the presence of NO essentially abrogated this peroxide-mediated cytotoxic effect on mesencephalic cells.
ερωτώ θεωρητικά
μήπως το δέρμα του κεφαλιού μου για να αντιμετωπίσει το οξυζενέ αυξάνει τα επίπεδα του Νο που προστατέυουν τα κύτταρα απο την οξείδωση ? και συνάμα δίνει κάποιο κλικ για επανέκφυση? δεν ξέρω πολύ tricky...
και όχι τπτ άλλο έχασα και το μνμ του Robert Που πιθανώς θα έκραζε μόνο εμένα λες και εγώ άνοιξα το θρεντ ..... :chinscratch
