Απ: Schwarzkopf Activ M, Dr Hoting Tonic For Men
Το ActivM έχει ως ενεργό συστατικό το Carnitine Tartrate το οποίο σε μια έρευνα που έγινε λέει ότι βοήθα στην τριχοφυΐα
Παραθέτω την περίληψη της έρευνας
L-carnitine-L-tartrate promotes human hair growth in vitro – Source: Experimental Dermatology, Nov 2007
by K Foitzik, et al. ImmuneSupport.com
11-12-2007
[Note: L-carnitine supports the transport of fatty acid “fuel” into the cells’ energy-producing mitochondria.]
The trimethylated amino acid l-carnitine plays a key role in the intramitochondrial transport of fatty acids for beta-oxidation and thus serves important functions in energy metabolism.
Here, we have tested the hypothesis that l-carnitine, a frequently employed dietary supplement, may also stimulate hair growth by increasing energy supply to the massively proliferating and energy-consuming anagen hair matrix.
Hair follicles (HFs) in the anagen VI stage of the hair cycle were cultured in the presence of 0.5-50 microm of l-carnitine-l-tartrate (CT) for 9 days. At day 9, HFs treated with 5 microm or 0.5 microm of CT showed a moderate, but significant stimulation of hair shaft elongation compared with vehicle-treated controls (P < 0.05). Also, CT prolonged the duration of anagen VI, down regulated apoptosis (as measured by TUNEL assay) and up regulated proliferation (as measured by Ki67 immunohistology) of hair matrix keratinocytes (P < 0.5). By immunohistology, intrafollicular immunoreactivity for TGFbeta2, a key catagen-promoting growth factor, in the dermal papilla and TGF-beta II receptor protein in the outer root sheath and dermal papilla was down regulated.
As shown by caspase activity assay, caspase 3 and 7, which are known to initiate apoptosis, are down regulated at day 2 and day 4 after treatment of HFs with CT compared with vehicle-treated control indicating that CT has an immediate protective effect on HFs to undergo programmed cell death.
Our findings suggest that l-carnitine stimulates human scalp hair growth by up regulation of proliferation and down regulation of apoptosis in follicular keratinocytes in vitro.
They further encourage one to explore topical and nutraceutical administration of l-carnitine as a well-tolerated, relatively safe adjuvant treatment in the management of androgenetic alopecia and other forms of hair loss.
Source: Experimental Dermatology. 2007 Nov;16(11):936-45. PMID: 17927577, by Foitzik K, Hoting E, Förster T, Pertile P, Paus R. Department of Dermatology, University Hospital Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany.
Προσέξτε όμως τι λέει, ότι είναι in vitro (έρευνα στο εργαστηρίου) άρα έχουμε δουλεία ακόμη.
Τέλος σε αναζήτηση σε κάποιο site βρήκα και αυτό.
Πάντως εμένα δεν έπεισε.
L-carnitine, also known as y-tri methylami no-6-hydroxybutyrate or Vitamin By, is an effective agent for alleviating certain skin disorders. For a brief description of the metabolic activity of L-carnitine and the effectiveness of L-carnitine therapy for treatment of various skin disorders, reference is again made to U.S. Patent No. 4,839,159. While L-carnitine has been known to improve skin disorders, it has now been found that L-carnitine in conjunction with ascorbic acid (Vitamin C) and niacin improves the regrowth of hair when applied topically to the hair and scalp in a pharmaceutically acceptable carrier.
L-carnitine, ascorbic acid and niacin are all readily available from a number of commercial suppliers.
The pharmaceutically, acceptable carrier may be in the form of aqueous and non-aqueous solutions, ointments, lotions, gels, suspensions, emulsions, and creams. The composition may be manufactured using carriers prepared according to conventional techniques using, conventional ingredients and agents which are well known in the industry. Adjuvants and other agents which may also be dispersed in the carrier include the following: moisturizers, humectants, anti-dusting agents, emulsifiers, and selected amino acids.
The composition may contain any effective amount of L-carnitine, ascorbic acid and niacin. However, the composition preferably contains ascorbic acid and L-carnitine in a weight/weight ratio of about 3:2. One formulation of the carrier (as an emulsion) utilizes distilled water, glycerin as a humectant, And sorbitol as an emulsifier. In a 3 ml. sample of the composition, 1000 mg of L-carnitine, 1500 mg ascorbic acid, and 60 mg niacin are dispersed in an emulsion formed from distilled water, glycerin, and sorbitol.
The compositions will be applied topically to the hair and scalp.
Usually the composition will be applied at least once per day for several weeks, and more preferably at least twice per day for several weeks. It also is contemplated to continue use of the composition for prolonged periods of time such as, for example, several months or several years. The duration of use depends in part upon the how long the user's hair has been thinning.
Initial results are usually visible within the first 30 days of use, and often within 7-14 days of use. It is preferred to apply the composition to the hair and scalp following treatment of the scalp with hot water. For example, the composition may be applied following a hot, shower or following the treatment of the hair and scalp with a towel soaked in hot water. In addition, the course of treating the hair and scalp with a composition of the present invention may be supplemented with oral doses of L-carnitine containing between about 300-600 mg. It is contemplated that such oral doses of L-carnitine will be necessary only for persons over 30 years of age.
In addition to the compositions described above, the present invention also provides a method for improving regrowth of hair using the previously described compositions. The method includes the step of applying the composition to the hair and scalp at least once per day. The preferred method also includes treating the hair and scalp with hot water, as described above, prior to applying the composition. In addition, the method may also include the consumption of an oral dose of L-carnitine.
It should be understood that the following Examples are offered as only to illustrate the preferred embodiments and that the examples are intended in no way to limit the scope of the invention.
Example 1 User 1, a thirty year old male with a receding hair line, used the composition of the present invention for seventeen weeks in accordance with the described method of use. Following two weeks of use, new hair growth was visible and new hair was beginning to thicken within approximately one half inch from the receding hair line. Following seventeen weeks of use, user 1 stopped treatment with the composition. Since cessation of treatment, the new hair growth remained firmly rooted in the scalp. No additional new hair growth occurred following cessation of treatment.
Example 2 User 2, a thirty-seven year old male with visibly thin patches of hair, used the composition of the present invention for four weeks in accordance with the described method of use. Following two weeks of use, noticeable thickening of the thin patches of hair occurred. User 2 is continuing treatment with the composition.
Example 3 User 3, a thirty-five year old male with distinct bald patches and thinning hair, used the composition for thirty-six weeks in accordance with the described method of use. Following three weeks of treatment, new hair growth was visibly noticeable. Following four weeks of treatment, thinning patches of hair had begun to thicken. Following twenty weeks of use, bald patches had begun filling with new hair growth. User 3 is continuing treatment with the composition.
While the invention has been described in conjunction with various preferred embodiments thereof, it will be understood that it is capable of further modifications. The claims are intended to cover any variation, use or adaptations of the invention which are generally consistent with the principles of the invention, and including such departures from the invention as come within known and customary practice within the art to which the invention pertains.
Industrial Applicabilitv There is a high degree of sensitivity to the loss of hair and developing baldness. The exact cause of balding may be due to aging, chemical damage, or afflictions such as alopecia. Of these, balding due to the process of aging results in the greatest number of cases. The sensitivity to balding has created a significant consumer demand for products which combat male pattern baldness, and there are a number of existing formulations which purport to increase hair growth. However, their effectiveness is questionable.
Nevertheless, there is a demand even for marginally effective formulations.
Those that are proven effective enjoy an immense consumer demand. The present formulation and method of application has proven itself effective on numerous occasions, and this effectiveness is uniquely attributable to the topical use L-carnitine, ascorbic acid, and niacin in a pharmaceutically acceptable carrier. The composition of the present invention is inexpensive, dependable and fully effective in accomplishing its intended purposes.
