Συμπληρώνω στο post και τις έρευνες για το fo-ti
Για τα μαλλιά:
1. Promotion effect of constituents from the root of Polygonum multiflorum on hair growth.
Abstract
Two new compounds, gallic acid ester of torachrysone-8-O-β-D-glucoside (1) and (E)-2,3,5,4'-tetrahydroxystilbene-2-O-β-D-xyloside (4), along with eight known compounds (2, 3, 5-10) were isolated from a 70% ethanol extract of Polygonum multiflorum roots. The structures were determined by (1)H and (13)C NMR, HMQC, and HMBC spectrometry. Extracts of P. multiflorum have been reported to promote hair growth in vivo. This study was carried out to evaluate the effects of isolated compounds from P. multiflorum on promoting hair growth using dermal papilla cells (DPCs), which play an important role in hair growth. When DPCs were treated with compounds (1-10) from P. multiflorum, compounds 1, 2, 3, 6, and 10 increased the proliferation of DPCs compared with the control. Specifically, compound 2 (10 and 20 μM) induced a greater increase in the proliferation of DPCs than minoxidil (10 μM). Additionally, treatment of vibrissa follicles with compound 2 for 21 days increased hair-fiber length significantly. On the basis of this result, further investigation and optimization of these derivatives might help in the development of therapeutic agents for the treatment of alopecia.
link έρευνας
αντιφλεγμονώδη ιδιότητες:
1. Li RW et al. "Anti-inflammatory activity of Chinese medicinal vine plants". Journal of Ethnopharmacology. 85.1 (2003):61-7.
αθηροσκλήρωση:
1.Yang PY et al. "Reduction of atherosclerosis in cholesterol-fed rabbits and decrease of expressions of intracellular adhesion molecule-1 and vascular endothelial growth factor in foam cells by a water-soluble fraction of Polygonum multiflorum". Journal of Pharmacology Sciences. 99.3 (2005):294-300.
οιστρογονική δράση:
1.Zhang CZ et al. "In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms". Journal of Ethnopharmacology. 98.3 (2005):295-300.
βελτίωση νοητικών διεργασιών:
1.Protective effect of Polygonum multiflorum Thunb on amyloid beta-peptide 25-35 induced cognitive deficits in mice.
J Ethnopharmacol. 2006. Food Function Research Division, Korea Food Research Institute, Seongnam 463-746, Republic of Korea.
Amyloid beta protein (Abeta) may be neurotoxic during the progression of Alzheimer's disease by eliciting oxidative stress. This study was designed to determine the effect of Polygonum multiflorum Thunb water extract He Shoo Wu on Abeta25-35-induced cognitive deficits and oxidative stress in mice. Mice were fed experimental diets comprising either 0.5 or 1% He Shoo Wu for 4 weeks, and then received a single intracerebroventricular injection of Abeta25-35. Behavioral changes in the mice were evaluated using passive avoidance and water-maze tests. The consumption of He Shoo Wu significantly ameliorated the cognitive deficits caused by i.c.v. injection of Abeta25-35. Our findings suggest that He Shoo Wu exerts a preventive effect against cognitive deficits induced by Abeta25-35 accumulation in Alzheimer's disease, and that this effect is mediated by the antioxidant properties of He Shoo Wu.
Για τα μαλλιά:
1. Promotion effect of constituents from the root of Polygonum multiflorum on hair growth.
Abstract
Two new compounds, gallic acid ester of torachrysone-8-O-β-D-glucoside (1) and (E)-2,3,5,4'-tetrahydroxystilbene-2-O-β-D-xyloside (4), along with eight known compounds (2, 3, 5-10) were isolated from a 70% ethanol extract of Polygonum multiflorum roots. The structures were determined by (1)H and (13)C NMR, HMQC, and HMBC spectrometry. Extracts of P. multiflorum have been reported to promote hair growth in vivo. This study was carried out to evaluate the effects of isolated compounds from P. multiflorum on promoting hair growth using dermal papilla cells (DPCs), which play an important role in hair growth. When DPCs were treated with compounds (1-10) from P. multiflorum, compounds 1, 2, 3, 6, and 10 increased the proliferation of DPCs compared with the control. Specifically, compound 2 (10 and 20 μM) induced a greater increase in the proliferation of DPCs than minoxidil (10 μM). Additionally, treatment of vibrissa follicles with compound 2 for 21 days increased hair-fiber length significantly. On the basis of this result, further investigation and optimization of these derivatives might help in the development of therapeutic agents for the treatment of alopecia.
link έρευνας
αντιφλεγμονώδη ιδιότητες:
1. Li RW et al. "Anti-inflammatory activity of Chinese medicinal vine plants". Journal of Ethnopharmacology. 85.1 (2003):61-7.
αθηροσκλήρωση:
1.Yang PY et al. "Reduction of atherosclerosis in cholesterol-fed rabbits and decrease of expressions of intracellular adhesion molecule-1 and vascular endothelial growth factor in foam cells by a water-soluble fraction of Polygonum multiflorum". Journal of Pharmacology Sciences. 99.3 (2005):294-300.
οιστρογονική δράση:
1.Zhang CZ et al. "In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms". Journal of Ethnopharmacology. 98.3 (2005):295-300.
βελτίωση νοητικών διεργασιών:
1.Protective effect of Polygonum multiflorum Thunb on amyloid beta-peptide 25-35 induced cognitive deficits in mice.
J Ethnopharmacol. 2006. Food Function Research Division, Korea Food Research Institute, Seongnam 463-746, Republic of Korea.
Amyloid beta protein (Abeta) may be neurotoxic during the progression of Alzheimer's disease by eliciting oxidative stress. This study was designed to determine the effect of Polygonum multiflorum Thunb water extract He Shoo Wu on Abeta25-35-induced cognitive deficits and oxidative stress in mice. Mice were fed experimental diets comprising either 0.5 or 1% He Shoo Wu for 4 weeks, and then received a single intracerebroventricular injection of Abeta25-35. Behavioral changes in the mice were evaluated using passive avoidance and water-maze tests. The consumption of He Shoo Wu significantly ameliorated the cognitive deficits caused by i.c.v. injection of Abeta25-35. Our findings suggest that He Shoo Wu exerts a preventive effect against cognitive deficits induced by Abeta25-35 accumulation in Alzheimer's disease, and that this effect is mediated by the antioxidant properties of He Shoo Wu.