Stephen,
Have you seen the getfitinib "regrowth" photo? The one in the front of a bald man's head?
Have you seen the getfitnib nose hair photo? Where that cancer patient had whisker-like dark hairs all over there nose?
I really and truly believe Follica is about to have a real solution for baldness based on their experiments. So does TAGOHL.
Its actually pretty simple. They will dermabrade the scalp, and use a topical immunosouppressant cream (probably the one used for eczema already in use) and use a EGF-receptor antagnonizing drug that is used for cancer patients in the cream formulation. That is really "it". Any thing else in their patent is just adjuvants to increase yield, but not necessary (anti-inflammatories, minoxidil, anti-histamines).
If you've not seen the head regrowth photo...................its really "new" hair. The guy was going grey, but had dark brown to black hair right in the front of his bald head. Sunburn is almost assuredly the reason he got the growth up there because it induced a state of re-epilithialization and he got on getfinib at just the right time after re-epilithialization was complete---so the keratinocytes were covering the wound just like the patent says. He'd been on chemo so his immune system couldn't respond to the inflammation----hence he got a bunch of hair on long long long bald scalp (he was a NW 6 or so).
There is verbiage in their patent about using the ectodsypslasin DNA sequences. That is probably way in the future, but ectodsypslasin goes along with the androgen receptor gene when skin is growing over a fetus' head in the mother's womb in the first trimester and probably shapes the wreath area as well as helps encode for the level of androgen receptor expression in target organs there. Hopefully, they will be able to one day silence this gene while the make the new hair in this embryonic "window" when the new hairs are made out of your skin's stem cells. There was a good interview with Cotsarialis on NBC's "The Today Show" discussing all of this with Dr. Nancy Snyderman (the NBC medical correspondent) and Matt Lauer. The ball is really rolling on this thing at this point.
IN their initial experiments, Follica was able to simply abrade human skin grafted onto SCID mice, and get hair to be formed where there was none (it was discarded donor-area skin from a hair transplant that had its follicles removed in the surgery). They found they could get much more hair (and larger hairs) if they blocked epidermal growth factor. Daphne Zohar stated in an interview that Follica would be using two FDA approved drugs with their procedure that have been approved for things "other than hairgrowth". Im almost certain from reading their patents that these two will be a topical immunosuppressant (they name five of them in their patent--rampycin, tacromilius, pimecromilus, cyclosporin, and one other) and an EGF-antagonist (almost assuredly getfitinib). The patent claims they will be able to generate hair growth in scars, on eyebrows etc. It worked everywhere on the mice, even genetically hairless mice.
αυτη ειναι η γνωμη καποιου ψαγμενου ποστερ για το πως θα ειναι το φαρμακο της follica γενικα μεσα απο τις πατεντες που εχει κανει αυτη η εταιρεια.πανω σε αυτα πειραματιζονται μερικοι μηπως και βρουν καποια λυση.
Have you seen the getfitinib "regrowth" photo? The one in the front of a bald man's head?
Have you seen the getfitnib nose hair photo? Where that cancer patient had whisker-like dark hairs all over there nose?
I really and truly believe Follica is about to have a real solution for baldness based on their experiments. So does TAGOHL.
Its actually pretty simple. They will dermabrade the scalp, and use a topical immunosouppressant cream (probably the one used for eczema already in use) and use a EGF-receptor antagnonizing drug that is used for cancer patients in the cream formulation. That is really "it". Any thing else in their patent is just adjuvants to increase yield, but not necessary (anti-inflammatories, minoxidil, anti-histamines).
If you've not seen the head regrowth photo...................its really "new" hair. The guy was going grey, but had dark brown to black hair right in the front of his bald head. Sunburn is almost assuredly the reason he got the growth up there because it induced a state of re-epilithialization and he got on getfinib at just the right time after re-epilithialization was complete---so the keratinocytes were covering the wound just like the patent says. He'd been on chemo so his immune system couldn't respond to the inflammation----hence he got a bunch of hair on long long long bald scalp (he was a NW 6 or so).
There is verbiage in their patent about using the ectodsypslasin DNA sequences. That is probably way in the future, but ectodsypslasin goes along with the androgen receptor gene when skin is growing over a fetus' head in the mother's womb in the first trimester and probably shapes the wreath area as well as helps encode for the level of androgen receptor expression in target organs there. Hopefully, they will be able to one day silence this gene while the make the new hair in this embryonic "window" when the new hairs are made out of your skin's stem cells. There was a good interview with Cotsarialis on NBC's "The Today Show" discussing all of this with Dr. Nancy Snyderman (the NBC medical correspondent) and Matt Lauer. The ball is really rolling on this thing at this point.
IN their initial experiments, Follica was able to simply abrade human skin grafted onto SCID mice, and get hair to be formed where there was none (it was discarded donor-area skin from a hair transplant that had its follicles removed in the surgery). They found they could get much more hair (and larger hairs) if they blocked epidermal growth factor. Daphne Zohar stated in an interview that Follica would be using two FDA approved drugs with their procedure that have been approved for things "other than hairgrowth". Im almost certain from reading their patents that these two will be a topical immunosuppressant (they name five of them in their patent--rampycin, tacromilius, pimecromilus, cyclosporin, and one other) and an EGF-antagonist (almost assuredly getfitinib). The patent claims they will be able to generate hair growth in scars, on eyebrows etc. It worked everywhere on the mice, even genetically hairless mice.
αυτη ειναι η γνωμη καποιου ψαγμενου ποστερ για το πως θα ειναι το φαρμακο της follica γενικα μεσα απο τις πατεντες που εχει κανει αυτη η εταιρεια.πανω σε αυτα πειραματιζονται μερικοι μηπως και βρουν καποια λυση.
