Απ: Για όσους θέλουν να πάρουν Proscar....
Σεβομενος την επιθυμια του otherdude μεταφερω εδω την απαντηση μου στον skeptikisti σχετικα με την υπαρξη φυσιολογικα της dht (Fenimore μπορεις να διαγραψεις το μηνυμα μου εδω
http://www.hairlossgr.com/forum/index.php/topic,3248.msg59060/topicseen.html#new γιατι δεν ξερω πως γινεται?)
Τα παντα ολα επανω μας εχουν λογο υπαρξης ...
Απο αυτο το αρθρο για τα ποντικια
http://www.ncbi.nlm.nih.gov/pubmed/832639
κραταμε το: The characteristics of DHT brain and pituitary cell nuclear binding are compared with the respective characteristics of neural cytosol and ventral prostate nuclear androgen binding components
Ακομη,
Effects of testosterone metabolites on copulation, medial preoptic dopamine, and NOS-immunoreactivity in castrated male rats
Susan K. Putnam1, Satoru Sato, Jon V. Riolo and Elaine M. HullCorresponding Author Contact Information, E-mail The Corresponding Author
Department of Psychology, State University of New York at Buffalo, Buffalo, NY 14260-4110, USA
The medial preoptic area (MPOA) is an important integrative site for male sexual behavior. Dopamine (DA) is released in the MPOA of male rats shortly before and during copulation. In a previous study, we identified 17β-estradiol (E2) as the metabolite of testosterone (T) that maintains MPOA basal extracellular DA levels. However, the presence of dihydrotestosterone (DHT), an androgenic metabolite of T, is required for the female-induced increase in MPOA DA observed during copulation. Recently, we reported that assays of MPOA tissue DA content showed that castrates actually had more stored DA than did gonadally intact males. Therefore, the reduction in extracellular levels in castrates was not due to decreased availability of DA; most likely it was due to decreased release. Furthermore, T upregulates neuronal nitric oxide synthase (nNOS) in the MPOA. NO has been implicated in the regulation of DA release in the MPOA. It is not known, however, which metabolite(s) of T regulate(s) tissue stores of DA and/or nNOS in the MPOA of male rats.
The present experiments were designed to test the following: (1) whether E2, DHT, or the combination of the two influences MPOA DA tissue levels, an indication of stored DA, in male rat castrates; and (2) whether E2, DHT, or the combination of the two influences NOS-ir in the MPOA of castrated male rats.
Επισης, The latest research in mice raises a disturbing question about the
safety of FDA approved 5AR inhibitors like finasteride
(Proscar/Propecia) and especially dutasteride (Avodart) when it comes to
managing long-term risk for neurodegenerative diseases like Alzheimer's.
This is because these drugs not only reduce levels of DHT but also wound
allopregnanolone production in the process.
πηγη:
http://www.bio.net/bionet/mm/neur-sci/2004-August/058929.html
Βασικα το προβλημα ειναι οτι η ελλειψη dht λογω μπλοκαρισματος της δρασης 5ar προκαλει αλυσιδωτες αντιδρασεις και σου γ@μ@ει ολο το ενδοκρινικο, ειδικα αμα παιρνεις ντουτα.
Αυτα μπορεσα τωρα προχειρα να βρω.
Εαν δεν σε καλυψα και βρω τπτα αλλο θα το προσθεσω.