Alpecin
- Έναρξη μίζας baldy
- Ημερομηνία έναρξης
Παρακαλώ συνδεθείτε ή εγγραφείτε για να απενεργοποιήσετε τις διαφημίσεις.
Νέα έρευνα που δείχνει την καφείνη ως πολύ δυνατό παίχτη...
Br J Dermatol. 2014 May 16. doi: 10.1111/bjd.13114. [Epub ahead of print]
Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and TGF-β2-/IGF-1-mediated regulation of hair cycle in male and female human hair follicles in vitro.
Fischer TW1, Herczeg-Lisztes E, Funk W, Zillikens D, Bíró T, Paus R.
Author information
Abstract
BACKGROUND:
Caffeine reportedly counteracts the suppression of hair shaft production by testosterone in organ-cultured male human hair follicles (HFs).
OBJECTIVES:
We aimed at investigating the impact of caffeine a) on additional key hair growth parameters, b) on major hair growth-regulatory growth factors and c) on male versus female HFs in the presence of testosterone.
METHODS:
Microdissected male and female human scalp HFs were treated in serum-free organ culture for 120 h with testosterone alone (0,5 μg/ml) or in combination with caffeine (0.005-0.0005%), and effects on hair shaft elongation, HF cycling (i.e. anagen-catagen transition), hair matrix keratinocyte proliferation and expression of a key catagen inducer, transforming growth factor β2 (TGF-β2), and anagen-prolonging insulin-like growth factor 1 (IGF-1) were evaluated by quantitative (immuno-) histomorphometry. Caffeine effects were further investigated in human outer root sheath keratinocytes (ORSK).
RESULTS:
Caffeine enhanced hair shaft elongation, prolonged anagen duration and stimulated hair matrix keratinocyte proliferation. Female HFs showed higher sensitivity to caffeine compared to male HFs. Caffeine counteracted testosterone-enhanced TGF-β2 protein expression in male HFs. In female HFs, testosterone failed to induce TGF-β2 expression, while caffeine reduced it. In male and female HFs, caffeine enhanced IGF-1 protein expression. In ORSK, caffeine stimulated cell proliferation, inhibited apoptosis/necrosis, up-regulated IGF-1 gene expression and protein secretion, while TGF-β2 protein secretion was down-regulated.
CONCLUSIONS:
This study reveals new growth-promoting effects of caffeine on human hair follicles of both genders at different (molecular, cellular and organ) levels. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
http://www.ncbi.nlm.nih.gov/pubmed/24836650
Br J Dermatol. 2014 May 16. doi: 10.1111/bjd.13114. [Epub ahead of print]
Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and TGF-β2-/IGF-1-mediated regulation of hair cycle in male and female human hair follicles in vitro.
Fischer TW1, Herczeg-Lisztes E, Funk W, Zillikens D, Bíró T, Paus R.
Author information
Abstract
BACKGROUND:
Caffeine reportedly counteracts the suppression of hair shaft production by testosterone in organ-cultured male human hair follicles (HFs).
OBJECTIVES:
We aimed at investigating the impact of caffeine a) on additional key hair growth parameters, b) on major hair growth-regulatory growth factors and c) on male versus female HFs in the presence of testosterone.
METHODS:
Microdissected male and female human scalp HFs were treated in serum-free organ culture for 120 h with testosterone alone (0,5 μg/ml) or in combination with caffeine (0.005-0.0005%), and effects on hair shaft elongation, HF cycling (i.e. anagen-catagen transition), hair matrix keratinocyte proliferation and expression of a key catagen inducer, transforming growth factor β2 (TGF-β2), and anagen-prolonging insulin-like growth factor 1 (IGF-1) were evaluated by quantitative (immuno-) histomorphometry. Caffeine effects were further investigated in human outer root sheath keratinocytes (ORSK).
RESULTS:
Caffeine enhanced hair shaft elongation, prolonged anagen duration and stimulated hair matrix keratinocyte proliferation. Female HFs showed higher sensitivity to caffeine compared to male HFs. Caffeine counteracted testosterone-enhanced TGF-β2 protein expression in male HFs. In female HFs, testosterone failed to induce TGF-β2 expression, while caffeine reduced it. In male and female HFs, caffeine enhanced IGF-1 protein expression. In ORSK, caffeine stimulated cell proliferation, inhibited apoptosis/necrosis, up-regulated IGF-1 gene expression and protein secretion, while TGF-β2 protein secretion was down-regulated.
CONCLUSIONS:
This study reveals new growth-promoting effects of caffeine on human hair follicles of both genders at different (molecular, cellular and organ) levels. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
http://www.ncbi.nlm.nih.gov/pubmed/24836650
A study conducted by Fischer et al. used hair organ culture model to investigate the effects of testosterone and caffeine on hair follicle growth stimulation.
This in vitro study used scalp biopsy samples from male AGA patients which were cultivated using different concentrations of testosterone and/or caffeine for a period of 120-192 hours.
Addition of caffeine in concentrations of 0.001% and 0.005% were found to counteract the suppressive effects of testosterone on hair growth, with a higher hair shaft elongation seen at 120 h after caffeine administration, compared to control group.
This in vitro study thus clearly demonstrates that caffeine is a stimulator of human hair growth which may have importance in the treatment of AGA
A recent study assessed the follicular penetration of caffeine on topical application in a shampoo formulation for 2 min and showed that penetration via hair follicles was faster and higher compared with the interfollicular route and that hair follicles were the only pathway for faster caffeine absorption during the first 20 min after application
The beneficial effects of topical application of caffeine in AGA can thus be attributed to inhibition of phosphodiesterase, improvement in barrier function, follicular penetration, stimulation and promotion of hair growth.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500065/
Οι έρευνες βέβαια είναι in vitro, αλλά φαίνεται η καφείνη να κάνει πολλά πράγματα, από το να εμποδίζει τη δράση της τεστοστερόνης στο θύλακα, να προκαλεί πολλαπλασιασμό κυττάρων, να αυξάνει τη διάμετρο του άξονα της τρίχας και γενικότερα φαίνεται ότι δημιουργεί προϋποθέσεις για regrowth μέσω της αύξησης του igf1.
Νομίζω η καλύτερη επιλογή από τα όσα κυκλοφορούν ήδη, είναι αυτό
http://www.ebay.com/sch/i.html?_trksid=p2054436.m570.l1313&_nkw=Caffeine+Powder+&_sacat=0&_from=R40
και είτε βάζουμε κάποια ποσότητα στο σαμπουάν ή/και φτιάχνουμε και κάποιο τοπικό.
http://www.ncbi.nlm.nih.gov/pubmed/17396054
Topical preparations using caffeine in high concentrations of about 1% of weight per unit volume or greater has a vasoconstrictive effect. Vasoconstriction is understood to decrease blood flow to the hair follicles, and thereby, inhibit hair growth. Thus, using caffeine for hair loss prevention in vivo is not found in the art. The present invention uses a concentration of caffeine (about 0.01 to about 0.19 mg/ml of caffeine, which is about 0.001% to about 0.019% weight of caffeine/final volume) that avoids vasoconstriction, but maintains its reducing effects on 5α-dihydrotestosterone (DHT).
This in vitro study used scalp biopsy samples from male AGA patients which were cultivated using different concentrations of testosterone and/or caffeine for a period of 120-192 hours.
Addition of caffeine in concentrations of 0.001% and 0.005% were found to counteract the suppressive effects of testosterone on hair growth, with a higher hair shaft elongation seen at 120 h after caffeine administration, compared to control group.
This in vitro study thus clearly demonstrates that caffeine is a stimulator of human hair growth which may have importance in the treatment of AGA
A recent study assessed the follicular penetration of caffeine on topical application in a shampoo formulation for 2 min and showed that penetration via hair follicles was faster and higher compared with the interfollicular route and that hair follicles were the only pathway for faster caffeine absorption during the first 20 min after application
The beneficial effects of topical application of caffeine in AGA can thus be attributed to inhibition of phosphodiesterase, improvement in barrier function, follicular penetration, stimulation and promotion of hair growth.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500065/
Οι έρευνες βέβαια είναι in vitro, αλλά φαίνεται η καφείνη να κάνει πολλά πράγματα, από το να εμποδίζει τη δράση της τεστοστερόνης στο θύλακα, να προκαλεί πολλαπλασιασμό κυττάρων, να αυξάνει τη διάμετρο του άξονα της τρίχας και γενικότερα φαίνεται ότι δημιουργεί προϋποθέσεις για regrowth μέσω της αύξησης του igf1.
Νομίζω η καλύτερη επιλογή από τα όσα κυκλοφορούν ήδη, είναι αυτό
http://www.ebay.com/sch/i.html?_trksid=p2054436.m570.l1313&_nkw=Caffeine+Powder+&_sacat=0&_from=R40
και είτε βάζουμε κάποια ποσότητα στο σαμπουάν ή/και φτιάχνουμε και κάποιο τοπικό.
http://www.ncbi.nlm.nih.gov/pubmed/17396054
Topical preparations using caffeine in high concentrations of about 1% of weight per unit volume or greater has a vasoconstrictive effect. Vasoconstriction is understood to decrease blood flow to the hair follicles, and thereby, inhibit hair growth. Thus, using caffeine for hair loss prevention in vivo is not found in the art. The present invention uses a concentration of caffeine (about 0.01 to about 0.19 mg/ml of caffeine, which is about 0.001% to about 0.019% weight of caffeine/final volume) that avoids vasoconstriction, but maintains its reducing effects on 5α-dihydrotestosterone (DHT).