Απ: airol
Λοιπον καπα διαβαζω μια ερευνα με τιτλο Endogenous retinoids in the hair follicle and sebaceous gland.Δυστυχως δεν με αφηνει να την αποθηκευσω για να την ανεβασω εδω.Γι'αυτο μαλλον φταιει το acrobat reader που δεν ειναι pro...τεσπα
Εκεινο που εχει σημασια ειναι οτι κανουν ερευνα σχετικα με τον εντοπισμο που εχουν τα ενδογενη RA στις στιβαδες που περιβαλουν το τριχ/κιο στις διαφορες φασεις και την επιπτωση που εχουν στον πολλαπλασιασμο καποιων βλαστοκυτταρων(Η ερευνα αναφερει ενα σωρο διαφορετικων πληθυσμων απο αυτα και μαλιστα βασιζονται στις μελετες του hoffman απο την replicel φτου-φτου
) Εν συντομια καταληγουν οτι τα ενδογενη ρετ. συντελλουν στην διατηρηση της αναγ.φασης (οταν λεμε ενδογενη αναφερομαστε σε αυτα που εμφανιζονται στα εσωτερικα στρωματα του θυλακου -αυτα που εφαπτονται με την τριχα). Ομως η εξωγενης παρουσια μονο κακο κανει (οπως σου ελεγα σε αλλη ερευνα) μαλιστα αναφερουν
Excess RA was found to reduce the number and length of hair follicles
in vitro [110]. Feather specification and dermal condensations
were also inhibited by excess RA, which altered the pattern of Hox
gene expression and NCAM in the developing feather, a structure similar
to the mammalian hair follicle [111]. In addition, Dgat1tm2FarTg
(KRT14-cre)1AMC null mice have cyclical hair loss that is restored
by reducing dietary vitamin A, as discussed above [6]. We found increased
expression of RA synthesis enzymes and binding proteins in
biopsies from patients with several hair loss diseases(Οπως η areata)
Σαν περιληψη λενε
The PSU is a complex mini-organ that is regulated by the same signaling
factors that regulate development of other organs. Similar to
organogenesis in other sites, RA synthesis enzymes, binding proteins,
receptors, and RA were seen in a specific temporal and spatial pattern.
This localization pattern and the fact that both vitamin A deficiency
and toxicity lead to defects in the PSU suggest that RA is important
for its function. Older work in the field laid the groundwork, but the
specific mechanisms by which RA regulates the PSU are just beginning
to be dissected. Future studies are needed to determine the
mechanisms by which: RA alters all of the stems cells in the PSU, RA
regulates differentiation of the PSU, and RA regulates sebaceous
gland function. In addition, future studies are needed to determine
what signaling factors regulate RA synthesis and how modulating
RA synthesis can be used to treat various diseases of the PSU such
as CCCA, AA, and acne.
Εδω λεει για τους σμ.αδενες
αυτο ειναι γνωστο:
while low levels of RA are important for sebaceous
gland function, excess RA synthesis within the sebaceous gland
could lead to atrophy of the gland, and reduced sebum production.
More recent studies suggest that 13cRA treats acne by both RAR dependent
and independent mechanisms. 13cRA does not bind to RARs,
but was shown to isomerizes to atRA in culture [131] and RARB and/
or RARG were reported to mediate the antiproliferative and antidifferentiative
affects of retinoids [132]. 13cRA induced apoptosis after 48
and 72 hours independent of RARs [133]. This long time frame suggests
an indirect mechanism. In addition to inhibiting genes involved in lipid
metabolism[134], 13cRA also inhibits androgen synthesis [135], FGFR2
signaling (reviewed in [136]), and genes involved in arachidonic acid
generation [134,137], which have all been implicated in acne
Αυτο εχει ενδιαφερον
Hair follicle stem cells are being tested for use in regenerative
medicine allowing a patient to be both the donor of the stem cells
and the recipient of these newly differentiated cells [70]. Initial studies
localized label retaining cells to the bulge region of the hair follicle
[71], Fig. 2). These bulge cells are quiescent, marked by
CD34 and Keratin
15 (Krt15), and express a unique signature of genes [72,73]. Results
from lineage tracing studies suggest
that these bulge stem cells
produce all of the cells in the hair follicle during the normal hair
cycle, but can repopulate the interfollicular epidermis (IFE) during
wound healing (reviewed in [74]). Six additional regions of potential
stem cells have since been reported (reviewed in [75]).
BLIMP1 marks
sebocyte stem cells that sit at the edge of the sebaceous gland duct
and give rise to all of the cells of the sebaceous gland, but no other
cells in the hair follicle or IFE δλαδη τα βλαστ. που ειναι στον αδενα δεν συμμετεχουν στον τριχοθυλακα
ουφ Μολις εφαγα 2 ωρες μεχρι να το βρω και να δω τι παιζει link αν μπορει κανεις να την ανεβασει...
http://www.sciencedirect.com/science?_ob=ArticleListURL&_method=list&_ArticleListID=1881506372&_sort=r&_st=13&view=c&_acct=C000059656&_version=1&_urlVersion=0&_userid=604493&md5=bb36871a489853e145d6ccbe2de45681&searchtype=a
