Pantostin

Pantostin
Το Pantostin είναι ένα τοπικό σκεύασμα, το οποίο περιέχει Alfatradiol η οποία μπορεί να περιορίσει την δράση του ενζύμου 5α-reductase και να περιορίσει έτσι την DHT.

Σχετικές έρευνες

7.5 months treatment with alfatradiol increased the proportion of frontal anagen hair statistically significantly, in women from 69 % to 77 % (means) and in men from 56 % to 65 %
Abstract
Androgenetic alopecia (AGA), also referred to as male pattern baldness, is the most common cause of hair loss in both sexes in adulthood. An option for topical treatment that selectively targets the metabolic pathways involved in the balding process is alfatradiol, an estrasterid without hormonal activity. In a drug monitoring study, efficacy and safety of alfatradiol (0.025 %) was assessed in 233 patients with AGA (192 women, aged 14 - 76 years, and 41 men, aged 17 - 56 years). After 7.5 months of treatment, trichograms of 112 patients (92 women, 20 men) were evaluated. Under treatment with alfatradiol the proportion of frontal anagen hair increased statistically significantly, in women from 69 % to 77 % (means) and in men from 56 % to 65 %. The proportion of telogen hair decreased accordingly. In 12 % of women and 21 % of men a further decline in the number of anagen hair was observed. Merely three patients (1,3 %) reported mild local adverse reactions. In conclusion, Alfatradiol appears to be effective and safe in the topical treatment of AGA in both men and women.
Comparison of the efficacy and safety of topical minoxidil and topical alfatradiol in the treatment of androgenetic alopecia in women.

RESULTS: Topical treatment with 2% minoxidil solution for 6 months resulted in a significant increase of cumulative hair thickness (p < 0.0001) and absolute hair density (p < or = 0.0025), whereas these parameters of hair growth remained nearly unchanged after 6 months of treatment with alfatradiol solution. Evaluation of the same parameters from month 7 to month 12 demonstrated that 12 months minoxidil treatment resulted in an increasing stabilization (group I). After the alfatradiol-->minoxidil switch in group II a significant increase in cumulative hair thickness (p < 0.0001) and absolute hair density (p < 0.0001) was achieved. Both study medications were well tolerated.
CONCLUSIONS: Treatment with minoxidil can induce an increase in hair density and hair thickness,whereas treatment with alfatradiol results in deceleration or stabilization of hair loss.
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24 Νοεμβρίου 2014