Απ: ΑΥΤΟ είναι το καλύτερο και φθηνότερο topical ....
TOPICAL SPIRONOLACTONE IN THE TREATMENT OF ALOPECIA ANDROGENETICA
It’s been firmly established that alopecia androgenetica, more commonly known as male pattern baldness, is initiated by dihydrotestosterone (DHT) attaching to androgen receptor sites on the hair follicles [1.2.3.4.].
Genetically, only the follicles on the top of the scalp are encoded with androgen receptor sites [5.6.24.], which explains why hair follicles along the side of the head and in the back of the head do not atrophy. The attached DHT on the receptor sites is perceived as a foreign body and the immune system begins to destroy the hair follicle, shortening the growth phase and causing the hair shaft to become progressively finer in texture [6]. In extreme cases, only a microscopic vellus hair remains. The good news is that these
follicles have the inherent capacity to mature to their former size and thickness.
Encouraged with the success of finasteride to reduce the amount of DHT in the scalp of patients with male pattern baldness (MPB), doctors and scientific researchers took another look at existing medications that are known to act as anti-androgens.
There have to be stringent criteria for an anti-androgen that can be used to combat or even reverse pattern alopecia. The ideal anti-androgen should have the following properties:
(1) It must have potent anti-androgen activity; (2) it should selectively prevent or successfully compete with DHT without changing testosterone levels; (3) it should be effective topically, so it can be conveniently applied with minoxidil solutions or lotions and (4), it should be easily absorbed into the skin, but should have no systemic effects.
That’s a tall order. Surprisingly, there is such a medication: spironolactone. And it’s not a new medication [7.8.]. For over thirty years spironolactone has been used for its anti-androgenic effects in both males and females [14.15.]. Taken orally, it is such a potent
anti-androgen that, although it is an effective anti-hypertensive drug, it is rarely used to treat men with hypertension because of its feminizing properties which can include painful gynecomastia [16.17.].
Applied topically, however, spironolactone does not have systemic side effects [12.18.19.20.]. Clinical evaluators of topical applications of spironolactone concluded, "as far as the topical use is concerned, spironolactone seems to be highly effective with
absence of systemic effects"[19]. Physicians have been treating patients for MPB for well over fifteen years and there have not been any reports of systemic side effects. In my own research, the use of topical 5% spironolactone along with Xandrox 5% solution yielded improved results as compared to the use of Xandrox 5% alone. Likewise, the combination of 5% spironolactone with Regrowth's 5% minoxidil yielded improved results as compared to the use of 5% minoxidil used with daily 1 mg doses of finasteride
(with the added advantage of zero side effects).
Among its other properties as an anti-androgen, spironolactone is a potent competitive inhibitor of DHT at its androgen receptor sites [21]. As such, spironolactone effectively prevents DHT from attaching to the receptor sites on the hair follicles [22].
As a result, the follicles no longer atrophy and can mature again to their normal size. And they do so without decreasing the circulating levels of DHT in the body. By comparison, finasteride inhibits the formation of systemic DHT, causing troublesome side effects in many patients.
Multiple studies in various medical centers document that spironolactone is effective when applied topically [22]. In studying the anti-androgenic effects of topical spironolactone at the Department of Dermatology at New York University School of Medicine, researchers established that spironolactone concentrations of 0.01% to 5% produced a dose responsive decrease [23]. When both topical 5% spironolactone and topical 5% minoxidil are used daily in the treatment of MPB, the effects of the medications are synergistic. Whereas neither medication alone is particularly effective for the majority of patients, the success of the combination has been experimentally proven. Our own success rate with this formulation has been approximately 75-80%.
Do not combine medications containing spironolactone and minoxidil in the same container. The medications slowly react with each other, resulting in a compromise of their pharmacological activities. However, since it requires many hours for spironolactone and minoxidil to chemically react with each other, they can be consecutively applied to the scalp without compromising the pharmacological action of component.
Bibliography:
1. Hamilton JB: Male hormone stimulation is prerequisite and an incitant in common baldness. Am J Anat 71:451-480, 1942
2. Rattner H: Ordinary baldness. Arch Dermatol Syph 44:201-213, 1941
3. Rook A, Dawber R: Diseases of the Hair and Scalp. Oxford, Blackwell Scientific Publications, 1982
4. Baden HP: Diseases of the Hair and Nails. Chicago, Year Book Medical Publishers, 1987
5. Lattanand A, Johnson WC: Male pattern alopecia: A histopathologic and histochemical study. J Cutan Pathol 2:58-70, 1975
6. Blauer M, Vaalasti A, Pauli SL, Ylikomi T, Joensuu T, Tuohimaa P: Location of androgen receptor in human skin. J Invest Dermatol 97:264-268, 1991
7. Menard RH, Stripp B, Gillette JR: Spironolactone and testicular cytochrome P-450: Decreased testosterone formation in several species and changes in hepatic drug metabolism. Endocrinology 1974;94:1628-1636
8. Menard RH, Martin HF, Stripp B, et al: Spironolactone and cytochrome P-450: Impairment of steroid hydroxylation in the adrenal cortex. Life Sci 1975;15:1639-1648
9. Schapiro G and Evron S. A novel use of Spironolactone:treatment of hirsutism. J Clin Endocrinol Metab. 1988;51:429-432
10. Cumming D, Yang J, Rebar R, Yen S.: Treatment of hirsutism with Spironolactone. JAMA. 1982;247:1295-8.
11. Boiselle A, Tremblay RR: Clinical usefulness of spironolactone in the treatment of acne and hirsutism, abstracted. Clin Res 1978;26:840A
12. Yamamoto A, Ito M. Topical spironolactone reduces sebum secretion rates in young adults. J Dermatol, 1996 Apr,23:4,243-6
13. Berardesca E, Gabba P, Ucci G, Borroni G, Rabbiosi G: Topical spironolactone inhibits dihydrotestosterone receptors in human sebaceous glands: an autoradiographic study in subjects with acne vulgaris. Int J Tissue React 10:115-119, 1988
14. Burke BM, Cunliffe WJ: Oral spironolactone therapy for female patients with acne, hirsutism or androgenetic alopecia. Br J Dermatol 112:124-125, 1985
15. Stripp B, Taylor AA, Bartter FC, et al: Effect of spironolactone on sex hormones in man. J Clin Endocrinol Metabol 1975;41:777-781
16. Mann NM: Gynecomastia during therapy with spironolactone. JAMA 190:160-162,1963
17. Rose LI, Underwood RH, Newmark SR, Kisch ES, Williams GH: Pathophysiology of spironolactone-induced gynecomastia. Ann Int Med 87:398-403, 1977
18. Corval P, Michaued A, Menard J, et al: Antiandrogenic effect of spironolactones: Mechanism of action. Endocrinology 1975;97:52-8
19. Messina M, Manieri C, Musso MC, Pastorino R.: Oral and topical spironolactone therapies in skin androgenization. Anminerva Med, 1990 Apr-Jun,32:2,49-55
20. Wendt A, Hasan SH, Heinz I, Tauber U: Systemic effects of local antiandrogen therapy. Arch Dermatol Res 273:171,1982
21. Price VH: Testosterone metabolism in the skin: A review of its function in androgenetic alopecia, acne vulgaris, and idiopathic hirsutism including recent studies with antiandrogens. Arch Dermatol 1975;111:1496-1502
22. Stoughton RB: Penetration of drugs through the skin. Dermatologica 152 (suppl): 27-36, 1976
23. Matias JR, Malloy V, Orentreich N: Synergistic antiandrogenic effects of topical combinations of 5 alpha reductase and androgen receptor inhibitors in the hamster sebaceous glands. J Invest Dermatol 91:429-433, 1988
24. Takayasu S, Wakimoto H, Itami S, Sano S: Activity of testosterone 5 alpha-reductase in various tissues of human skin. J Invest Dermatol 74:187-191,1980
25. Sawaya ME, Hoenig LS, Hsia SL: Increased androgen binding capacity in sebaceous glands in scalp of male pattern baldness. J Invest Dermatol 92:91-95, 1988, Martin HF, Stripp B, et al: Spiro H
ΕΒΑΛΑ την βιβλιογραφια...η πηγη ειναι Dr.Lee ξανα.....
νομιζω οτι μολις τελειωσω με το revivogen θα το ριξω εκει και αν τελικα καταληξω ισως δοκιμασω τοπικη χρηση ντουταστεριδης η φιναστεριδης....
για SPIRONOLACTONE εχω ακουσει μονο καλα λογια και ισως ουτε ενα κακο.....